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Vps53
Gene Detail
 Symbol
Name
ID
Vps53
vacuolar protein sorting 53 (yeast)
MGI:1915549
Synonyms 2010002A08Rik, 2310040I21Rik, 3100002B05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.92 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:76046226-76179647 bp, - strand
From VEGA annotation of GRCm38

  133422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Vps53

Human
homologs
Human Homolog VPS53, vacuolar protein sorting 53 homolog (S. cerevisiae)
NCBI Gene ID 55275
neXtProt AC  NX_Q5VIR6
Human Synonyms  HCCS1, hVps53L, PCH2E, pp13624
Human Chr (Location)  17p13.3; chr17:508668-714856 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human VPS53
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E12.5 with trophoblast cell hyperplasia.
 
Interactions
Vps53 interacts with 245 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process protein transport, transport
Component endosome, GARP complex, ...
External Resources: FuncBase
Expression
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) cDNA(99)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000006225 (Evidence)
Ensembl Gene ModelENSMUSG00000017288 (Evidence)
Entrez Gene68299 (Evidence)
UniGene46397
DFCITC1574333, TC1621946, TC1650783
DoTSDT.110512592, DT.491968, DT.55168430, DT.87072264, DT.97336857
Consensus CDS ProjectCCDS25060.1
International Mouse Knockout Project StatusVps53
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006225 VEGA Gene Model | MGI Sequence Detail 133422 C57BL/6J ±  kb
transcript OTTMUST00000014053 VEGA | MGI Sequence Detail 2833 Not Applicable 
polypeptide OTTMUSP00000006529 VEGA | MGI Sequence Detail 832 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(6) UniProt(13)
Polymorphisms SNPs within 2kb(532 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007234 Vps53-like, N-terminal
Protein Ontology PR:000017345 vacuolar protein sorting-associated protein 53
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:1913804, MGI:1917090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory