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Edem2 Gene Detail
Summary
  • Symbol
    Edem2
  • Name
    ER degradation enhancer, mannosidase alpha-like 2
  • Synonyms
    9530090G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915540
    NCBI Gene: 108687
  • Gene Overview
    MyGene.info: EDEM2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155701677-155729475 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 77.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    198 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915540
protein coding gene Chr2:155701673-155729475 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026740
protein coding gene Chr2:160540185-160567853 (-)
A/J MGP_AJ_G0026706
protein coding gene Chr2:154160295-154188267 (-)
AKR/J MGP_AKRJ_G0026677
protein coding gene Chr2:158631957-158661444 (-)
BALB/cJ MGP_BALBcJ_G0026715
protein coding gene Chr2:154460610-154488142 (-)
C3H/HeJ MGP_C3HHeJ_G0026458
protein coding gene Chr2:158993527-159021126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027164
protein coding gene Chr2:165246331-165275036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024534
protein coding gene Chr2:147655564-147683833 (-)
CAST/EiJ MGP_CASTEiJ_G0025919
protein coding gene Chr2:159311291-159339413 (-)
CBA/J MGP_CBAJ_G0026435
protein coding gene Chr2:171250550-171278936 (-)
DBA/2J MGP_DBA2J_G0026572
protein coding gene Chr2:153338302-153372349 (-)
FVB/NJ MGP_FVBNJ_G0026539
protein coding gene Chr2:151716978-151744511 (-)
LP/J MGP_LPJ_G0026677
protein coding gene Chr2:160683617-160711305 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026560
protein coding gene Chr2:175235716-175264001 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027220
protein coding gene Chr2:158516578-158544121 (-)
PWK/PhJ MGP_PWKPhJ_G0025653
protein coding gene Chr2:152837744-152867534 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025456
protein coding gene Chr2:157450413-157481906 (-)
WSB/EiJ MGP_WSBEiJ_G0025989
protein coding gene Chr2:159406534-159435555 (-)



Homology
more
  • Human Ortholog
    EDEM2, ER degradation enhancing alpha-mannosidase like protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EDEM2, ER degradation enhancing alpha-mannosidase like protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA4204.1, C20orf31, C20orf49
  • Links
    NCBI Gene ID: 55741
    neXtProt AC: NX_Q9BV94
    UniProt: Q9BV94

  • Chr Location
    20q11.22; chr20:35115357-35147358 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038312 Ensembl Gene Model | MGI Sequence Detail 27799 C57BL/6J ±  kb
transcript ENSMUST00000040833 Ensembl | MGI Sequence Detail 2290 Not Applicable  
polypeptide ENSMUSP00000041202 Ensembl | MGI Sequence Detail 577 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001382 Glycoside hydrolase family 47
    IPR036026 Seven-hairpin glycosidases
    IPR012341 Six-hairpin glycosidase-like superfamily
Molecular
Reagents
less
  • All nucleic 104
    cDNA 104

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138917
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:208389 Slominska-Wojewodzka M, et al., The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol. Biochem J. 2014 Feb 1;457(3):485-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory