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Mcoln2 Gene Detail
Summary
  • Symbol
    Mcoln2
  • Name
    mucolipin 2
  • Synonyms
    3300002C04Rik, mucolipidin 2, TRPML2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915529
    NCBI Gene: 68279
  • Gene Overview
    MyGene.info: MCOLN2
Location & Maps
more
  • Sequence Map
    Chr3:146149833-146195513 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 71.03 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MCOLN2, mucolipin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCOLN2, mucolipin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TRPML2, TRP-ML2
  • Links
    NCBI Gene ID: 255231
    neXtProt AC: NX_Q8IZK6

  • Chr Location
    1p22; chr1:84925583-84997122 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Mcoln2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035947 VEGA Gene Model | MGI Sequence Detail 45681 C57BL/6J ±  kb
transcript OTTMUST00000092205 VEGA | MGI Sequence Detail 2520 Not Applicable  
polypeptide OTTMUSP00000050907 VEGA | MGI Sequence Detail 566 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    317 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010253 mucolipin-2
  • InterPro Domains
    IPR013122 Polycystin cation channel, PKD1/PKD2
Molecular
Reagents
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  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139754, MGI:2140099
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:222652 Remis NN, et al., Mucolipin co-deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure-to-thrive from birth to weaning. PLoS Genet. 2014 Dec;10(12):e1004833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory