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Lingo1 Gene Detail
Summary
  • Symbol
    Lingo1
  • Name
    leucine rich repeat and Ig domain containing 1
  • Synonyms
    4930471K13Rik, LERN1, LINGO-1, Lrrn6a, UNQ201
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915522
    NCBI Gene: 235402
  • Gene Overview
    MyGene.info: LINGO1
Location & Maps
more
  • Sequence Map
    Chr9:56618475-56685253 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.28 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LINGO1, leucine rich repeat and Ig domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LINGO1, leucine rich repeat and Ig domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LERN1, LRRN6A, UNQ201
  • Links
    NCBI Gene ID: 84894
    neXtProt AC: NX_Q96FE5

  • Chr Location
    15q24.3; chr15:77613024-77820900 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit early-onset CNS myelination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016697 VEGA Gene Model | MGI Sequence Detail 66779 C57BL/6J ±  kb
transcript OTTMUST00000040442 VEGA | MGI Sequence Detail 2782 Not Applicable  
polypeptide OTTMUSP00000018069 VEGA | MGI Sequence Detail 620 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    875 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009830 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
  • InterPro Domains
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 27
    cDNA 25
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:3034974
References
more
  • Summaries
    All 50
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229415 Liu G, et al., Expression of Nogo receptor 1 in microglia during development and following traumatic brain injury. Brain Res. 2015 Nov 19;1627:41-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory