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Dnaaf1 Gene Detail
Summary
  • Symbol
    Dnaaf1
  • Name
    dynein, axonemal assembly factor 1
  • Synonyms
    4930457P18Rik, Lrrc50, m4Bei
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915520
    NCBI Gene: 68270
  • Gene Overview
    MyGene.info: DNAAF1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:119575235-119598454 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 67.98 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915520
protein coding gene Chr8:119575235-119598454 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034186
protein coding gene Chr8:122907461-122935495 (+)
A/J MGP_AJ_G0034166
protein coding gene Chr8:117848984-117872081 (+)
AKR/J MGP_AKRJ_G0034093
protein coding gene Chr8:121267438-121295403 (+)
BALB/cJ MGP_BALBcJ_G0034160
protein coding gene Chr8:118052022-118076773 (+)
C3H/HeJ MGP_C3HHeJ_G0033871
protein coding gene Chr8:121997319-122022741 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034680
protein coding gene Chr8:127023461-127046652 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031622
protein coding gene Chr8:110741089-110767995 (+)
CAST/EiJ MGP_CASTEiJ_G0033198
protein coding gene Chr8:121938834-121965359 (+)
CBA/J MGP_CBAJ_G0033844
protein coding gene Chr8:131638625-131668345 (+)
DBA/2J MGP_DBA2J_G0034000
protein coding gene Chr8:117069837-117092787 (+)
FVB/NJ MGP_FVBNJ_G0033943
protein coding gene Chr8:116098729-116124358 (+)
LP/J MGP_LPJ_G0034089
protein coding gene Chr8:123048299-123077659 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033990
protein coding gene Chr8:134086202-134111232 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034698
protein coding gene Chr8:121419756-121447458 (+)
PWK/PhJ MGP_PWKPhJ_G0032900
protein coding gene Chr8:116823248-116847039 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032740
protein coding gene Chr8:120118703-120141668 (+)
WSB/EiJ MGP_WSBEiJ_G0033314
protein coding gene Chr8:122140178-122164331 (+)



Homology
more
  • Human Ortholog
    DNAAF1, dynein axonemal assembly factor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DNAAF1, dynein axonemal assembly factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD13, LRRC50, ODA7, swt
  • Links
    NCBI Gene ID: 123872
    neXtProt AC: NX_Q8NEP3
    UniProt: Q8NEP3

  • Chr Location
    16q24.1; chr16:84145260-84178761 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DNAAF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    4 phenotype references
Mice homozygous for an ENU-induced mutation exhibit partial postnatal lethality, domed cranium, enlarged lateral ventricles, abnormal hippocampus morphology, and thin cerebral cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68270 NCBI Gene Model | MGI Sequence Detail 23220 C57BL/6J ±  kb
transcript NM_026648 RefSeq | MGI Sequence Detail 2821 C57BL/6  
polypeptide Q9D2H9 UniProt | EBI | MGI Sequence Detail 634 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:5505437
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:240319 Stauber M, et al., Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2017 Mar 15;423(2):170-188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory