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Zdhhc21 Gene Detail
Summary
  • Symbol
    Zdhhc21
  • Name
    zinc finger, DHHC domain containing 21
  • Synonyms
    9130404H11Rik, D130004H04Rik, dep
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915518
    NCBI Gene: 68268
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:82716975-82778195 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 39.40 cM, cytoband C3
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3562 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915518
 protein coding gene Chr4:82716975-82778892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028399
 protein coding gene Chr4:82367760-82431658 (-)
A/J MGP_AJ_G0028360
 protein coding gene Chr4:79519540-79581085 (-)
AKR/J MGP_AKRJ_G0028309
 protein coding gene Chr4:81577474-81641851 (-)
BALB/cJ MGP_BALBcJ_G0028380
 protein coding gene Chr4:79752411-79815049 (-)
C3H/HeJ MGP_C3HHeJ_G0028095
 protein coding gene Chr4:82164661-82226707 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028819
 protein coding gene Chr4:85629866-85697461 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026119
 protein coding gene Chr4:75476771-75537817 (-)
CAST/EiJ MGP_CASTEiJ_G0027536
 protein coding gene Chr4:80062334-80128159 (-)
CBA/J MGP_CBAJ_G0028064
 protein coding gene Chr4:88283064-88348073 (-)
DBA/2J MGP_DBA2J_G0028213
 protein coding gene Chr4:79292808-79353653 (-)
FVB/NJ MGP_FVBNJ_G0028179
 protein coding gene Chr4:78289216-78350297 (-)
LP/J MGP_LPJ_G0028313
 protein coding gene Chr4:82710756-82780567 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028208
 protein coding gene Chr4:93379977-93448691 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028856
 protein coding gene Chr4:81626784-81693553 (-)
PWK/PhJ MGP_PWKPhJ_G0027259
 protein coding gene Chr4:77640435-77698448 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027084
 protein coding gene Chr4:79159464-79224200 (-)
WSB/EiJ MGP_WSBEiJ_G0027612
 protein coding gene Chr4:81810942-81873657 (-)



Homology
more
  • Human Ortholog
    ZDHHC21, zDHHC palmitoyltransferase 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC21, zDHHC palmitoyltransferase 21
  • Synonyms
    DHHC-21, DHHC21, DNZ1, HSPC097
  • Links
    NCBI Gene ID: 340481
    UniProt: Q8IVQ6

  • Chr Location
    9p22.3; chr9:14586766-14693432 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants of this epidermal acting gene have thin, short hair, many misshapen and disoriented hair follicles, and clumps of pigment reflecting remains of degenerating follicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    71
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028403 Ensembl Gene Model | MGI Sequence Detail 61221 C57BL/6J ±  kb
    transcript ENSMUST00000107239 Ensembl | MGI Sequence Detail 1148 Not Applicable  
    polypeptide ENSMUSP00000102859 Ensembl | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8829, MGI:2140413, MGI:94884
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 23
    • Earliest
      J:5722 Mayer TC, et al., Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis. Genetics. 1976 Sep;84(1):59-65
    • Latest
      J:327730 Bieerkehazhi S, et al., Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells. J Cell Sci. 2022 Mar 1;135(5):jcs258186
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory