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Zdhhc21 Gene Detail
Summary
  • Symbol
    Zdhhc21
  • Name
    zinc finger, DHHC domain containing 21
  • Synonyms
    9130404H11Rik, D130004H04Rik, dep
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915518
    NCBI Gene: 68268
Location & Maps
more
  • Sequence Map
    Chr4:82798738-82859958 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      61221 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 39.40 cM, cytoband C3
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    ZDHHC21, zinc finger DHHC-type containing 21
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZDHHC21, zinc finger DHHC-type containing 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHHC21, DHHC-21, DNZ1, HSPC097
  • Links
    NCBI Gene ID: 340481
    neXtProt AC: NX_Q8IVQ6
    UniProt: Q8IVQ6

  • Chr Location
    9p22.3; chr9:14588797-14693531 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Zdhhc21
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    9 strains or lines available
Homozygous mutants of this epidermal acting gene have thin, short hair, many misshapen and disoriented hair follicles, and clumps of pigment reflecting remains of degenerating follicles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    10
  • Tissues
    10
  • cDNA Data
    70
  • Literature Summary
    4
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000297 VEGA Gene Model | MGI Sequence Detail 61221 C57BL/6J ±  kb
transcript OTTMUST00000000764 VEGA | MGI Sequence Detail 8763 Not Applicable  
polypeptide OTTMUSP00000000336 VEGA | MGI Sequence Detail 265 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    680 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 70
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-8829, MGI:2140413, MGI:94884
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:20220 Green MC, New mutant: a new recessive mutation, depilated (dep), arose in our T tf/+ tf stock in 1966. Mouse News Lett. 1970;43:31
  • Latest
    J:242176 Beard RS Jr, et al., Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome. Nat Commun. 2016 Sep 22;7:12823
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory