Zdhhc21 MGI Mouse Gene Detail - MGI:1915518 - zinc finger, DHHC domain containing 21

Zdhhc21 Gene Detail

Symbol

Zdhhc21
Name

zinc finger, DHHC domain containing 21
Synonyms

9130404H11Rik, D130004H04Rik, dep

Feature Type

protein coding gene
IDs

MGI:1915518
NCBI Gene: 68268
Alliance

gene page

Sequence Map

Chr4:82798738-82859958 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

61221 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 39.40 cM, cytoband C3
Mapping Data

21 experiments

Human Ortholog

ZDHHC21, zinc finger DHHC-type containing 21

Vertebrate Orthologs

9

Human Ortholog

ZDHHC21, zinc finger DHHC-type containing 21
Orthology source: HomoloGene, HGNC
Synonyms

DHHC21, DHHC-21, DNZ1, HSPC097
Links

HGNC:20750

NCBI Gene ID: 340481

neXtProt AC: NX_Q8IVQ6

UniProt: Q8IVQ6
Chr Location

9p22.3; chr9:14588797-14693531 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 32668
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ZDHHC21
Protein SuperFamily

zinc finger DHHC domain-containing protein 7
Gene Tree

Zdhhc21

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Phenotype Summary

24 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Gene trapped

4
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Zdhhc21
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available

Homozygous mutants of this epidermal acting gene have thin, short hair, many misshapen and disoriented hair follicles, and clumps of pigment reflecting remains of degenerating follicles.

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All GO Annotations

14
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

10
Tissues

10
cDNA Data

70
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zdhhc21

ZFIN zdhhc21

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Zdhhc21 interacts with 499 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

59
RefSeq

15
UniProt

4
CCDS

CCDS18294.1
UniGene

32047

			Length	Strain/Species	Flank
genomic	OTTMUSG00000000297	VEGA Gene Model \| MGI Sequence Detail	61221	C57BL/6J	± kb
transcript	OTTMUST00000000764	VEGA \| MGI Sequence Detail	8763	Not Applicable
polypeptide	OTTMUSP00000000336	VEGA \| MGI Sequence Detail	265	Not Applicable

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SNPs within 2kb

680 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000032812 palmitoyltransferase ZDHHC21

(term hierarchy)
EC

2.3.1.225
InterPro Domains

IPR001594 Palmitoyltransferase, DHHC domain

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All nucleic 71

cDNA 70

Primer pair 1

Microarray probesets 4

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MGD-MRK-8829, MGI:2140413, MGI:94884

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 16
Earliest

J:5722 Mayer TC, et al., Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis. Genetics. 1976 Sep;84(1):59-65
Latest

J:250741 Haines RJ, et al., Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation. Am J Physiol Gastrointest Liver Physiol. 2017 Dec 1;313(6):G549-G557

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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