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Zdhhc21 Gene Detail
Summary
  • Symbol
    Zdhhc21
  • Name
    zinc finger, DHHC domain containing 21
  • Synonyms
    9130404H11Rik, D130004H04Rik, dep
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915518
    NCBI Gene: 68268
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:82798738-82859958 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      61221 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 39.40 cM, cytoband C3
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    ZDHHC21, zinc finger DHHC-type containing 21
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZDHHC21, zinc finger DHHC-type containing 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DHHC21, DHHC-21, DNZ1, HSPC097
  • Links
    NCBI Gene ID: 340481
    neXtProt AC: NX_Q8IVQ6
    UniProt: Q8IVQ6

  • Chr Location
    9p22.3; chr9:14588797-14693531 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants of this epidermal acting gene have thin, short hair, many misshapen and disoriented hair follicles, and clumps of pigment reflecting remains of degenerating follicles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    10
  • Tissues
    10
  • cDNA Data
    71
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000297 VEGA Gene Model | MGI Sequence Detail 61221 C57BL/6J ±  kb
    transcript OTTMUST00000000764 VEGA | MGI Sequence Detail 8763 Not Applicable  
    polypeptide OTTMUSP00000000336 VEGA | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      680 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8829, MGI:2140413, MGI:94884
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:5722 Mayer TC, et al., Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis. Genetics. 1976 Sep;84(1):59-65
    • Latest
      J:250741 Haines RJ, et al., Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation. Am J Physiol Gastrointest Liver Physiol. 2017 Dec 1;313(6):G549-G557
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory