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Pdhb
Gene Detail
Symbol

Name
ID
Pdhb
pyruvate dehydrogenase (lipoamide) beta
MGI:1915513
Synonyms
2610103L06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
4.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:8165991-8172992 bp, - strand
From NCBI annotation of GRCm38

  7002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDHB
Protein SuperFamily: thiamine pyrophosphate dependent dehydrogenase, E1 component, beta subunit
Gene Tree: Pdhb

Human
homologs
PDHB, pyruvate dehydrogenase (lipoamide) beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5162
neXtProt AC: NX_P11177

Human Synonyms: PDHBD, PDHE1-B, PHE1B

Human Chr (Location): 3p21.1-p14.2; chr3:58427630-58433852 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PDHB

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pdhb interacts with 83 markers (Mir7-2, Mir7b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component extracellular exosome, mitochondrion, ...
Function catalytic activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdhb ; ZFIN pdhb    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021748 (Evidence)
Entrez Gene 68263 (Evidence)
DFCI TC1573259, TC1584327, TC1647679
NIA Mouse Gene Index U045798, U035227
EC 1.2.4.1
Consensus CDS Project CCDS36800.1
International Mouse Phenotyping Consortium Status Pdhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 68263 NCBI Gene Model | MGI Sequence Detail 7002 C57BL/6J ±  kb
transcript NM_024221 RefSeq | MGI Sequence Detail 1485 C57BL/6 
polypeptide Q9D051 UniProt | EBI | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027110 Pyruvate dehydrogenase E1 component subunit beta
InterPro IPR005476 Transketolase, C-terminal
InterPro IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
InterPro IPR005475 Transketolase-like, pyrimidine-binding domain
Protein Ontology PR:000012495 pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:212391 Uslu VV, et al., Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014 Jul;46(7):753-8
All references(30)
Other
accession IDs
MGI:2145717, MGI:2145868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory