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Pdhb
Gene Detail
 Symbol
Name
ID
Pdhb
pyruvate dehydrogenase (lipoamide) beta
MGI:1915513
Synonyms 2610103L06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
4.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:8165991-8172992 bp, - strand
From NCBI annotation of GRCm38

  7002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: thiamine pyrophosphate dependent dehydrogenase, E1 component, beta subunit
Gene Tree: Pdhb

Human
homologs
Human Homolog PDHB, pyruvate dehydrogenase (lipoamide) beta
NCBI Gene ID 5162
neXtProt AC  NX_P11177
Human Synonyms  PDHBD, PDHE1-B, PHE1B
Human Chr (Location)  3p21.1-p14.2; chr3:58427630-58433852 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDHB
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pdhb interacts with 84 markers (Mir7-2, Mir7b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component extracellular vesicular exosome, mitochondrion, ...
Function catalytic activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (10)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000021748 (Evidence)
Entrez Gene68263 (Evidence)
DFCITC1573259, TC1584327, TC1647679
NIA Mouse Gene IndexU035227, U045798
EC1.2.4.1
Consensus CDS ProjectCCDS36800.1
International Mouse Knockout Project StatusPdhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 68263 NCBI Gene Model | MGI Sequence Detail 7002 C57BL/6J ±  kb
transcript NM_024221 RefSeq | MGI Sequence Detail 1485 C57BL/6 
polypeptide Q9D051 UniProt | EBI | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027110 Pyruvate dehydrogenase E1 component subunit beta
InterPro IPR005476 Transketolase, C-terminal
InterPro IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
InterPro IPR005475 Transketolase-like, pyrimidine-binding domain
Protein Ontology PR:000012495 pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)
Other
accession IDs
MGI:2145717, MGI:2145868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory