Pdhb
Gene Detail

Symbol Name ID

Pdhb pyruvate dehydrogenase (lipoamide) beta MGI:1915513

Synonyms

2610103L06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 14

4.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:8165991-8172992 bp, - strand From NCBI annotation of GRCm38   7002 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thiamine pyrophosphate dependent dehydrogenase, E1 component, beta subunit
Gene Tree: Pdhb

Human homologs

Human Homolog		PDHB, pyruvate dehydrogenase (lipoamide) beta
NCBI Gene ID		5162
neXtProt AC		NX_P11177
Human Synonyms		PDHBD, PDHE1-B, PHE1B
Human Chr (Location)		3p21.1-p14.2; chr3:58413357-58419579 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PDHB

Alleles and phenotypes

All alleles(2) : Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component	mitochondrion, pyruvate dehydrogenase complex
Function	catalytic activity, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (10)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000021748 (Evidence)
Entrez Gene	68263 (Evidence)
DFCI	TC1573259, TC1584327, TC1647679
NIA Mouse Gene Index	U035227, U045798
EC	1.2.4.1
Consensus CDS Project	CCDS36800.1
International Mouse Knockout Project Status	Pdhb

Sequences

Length	Strain/Species
genomic	68263	NCBI Gene Model | MGI Sequence Detail	7002	C57BL/6J
transcript	NM_024221	RefSeq | MGI Sequence Detail	1485	C57BL/6
polypeptide	Q9D051	UniProt | EBI | MGI Sequence Detail	359	Not Applicable

All sequences(32) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027110	Pyruvate dehydrogenase E1 component subunit beta
InterPro	IPR005476	Transketolase, C-terminal
InterPro	IPR009014	Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
InterPro	IPR015941	Transketolase-like, C-terminal
InterPro	IPR005475	Transketolase-like, pyrimidine-binding domain
Protein Ontology	PR:000012495	pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Other accession IDs

MGI:2145717, MGI:2145868