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Pdhb Gene Detail
Summary
  • Symbol
    Pdhb
  • Name
    pyruvate dehydrogenase (lipoamide) beta
  • Synonyms
    2610103L06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915513
    NCBI Gene: 68263
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:8165991-8172992 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 4.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915513
protein coding gene Chr14:8165991-8173025 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020989
protein coding gene Chr14:502204-509228 (-)
A/J MGP_AJ_G0020937
protein coding gene Chr14:479499-486536 (-)
AKR/J MGP_AKRJ_G0020914
protein coding gene Chr14:487319-494320 (-)
BALB/cJ MGP_BALBcJ_G0020939
protein coding gene Chr14:472601-479602 (-)
C3H/HeJ MGP_C3HHeJ_G0020724
protein coding gene Chr14:488305-504179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021373
protein coding gene Chr14:514726-521734 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018942
protein coding gene Chr14:1397620-1405366 (-)
CAST/EiJ MGP_CASTEiJ_G0020246
protein coding gene Chr14:491101-500963 (-)
CBA/J MGP_CBAJ_G0020690
protein coding gene Chr14:529151-536115 (-)
DBA/2J MGP_DBA2J_G0020813
protein coding gene Chr14:463077-470087 (-)
FVB/NJ MGP_FVBNJ_G0020795
protein coding gene Chr14:459012-466022 (-)
LP/J MGP_LPJ_G0020890
protein coding gene Chr14:481342-488333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020821
protein coding gene Chr14:510008-521594 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021406
protein coding gene Chr14:486168-493169 (-)
PWK/PhJ MGP_PWKPhJ_G0019998
protein coding gene Chr14:482117-489678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019819
protein coding gene Chr14:497684-505120 (-)
WSB/EiJ MGP_WSBEiJ_G0020304
protein coding gene Chr14:481381-488450 (-)



Homology
more
  • Human Ortholog
    PDHB, pyruvate dehydrogenase E1 beta subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDHB, pyruvate dehydrogenase E1 beta subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PDHBD, PDHE1B, PDHE1-B, PHE1B
  • Links
    NCBI Gene ID: 5162
    neXtProt AC: NX_P11177
    UniProt: P11177

  • Chr Location
    3p14.3; chr3:58427630-58433852 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PDHB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68263 NCBI Gene Model | MGI Sequence Detail 7002 C57BL/6J ±  kb
transcript NM_024221 RefSeq | MGI Sequence Detail 1485 C57BL/6  
polypeptide Q9D051 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012495 pyruvate dehydrogenase E1 component subunit beta, mitochondrial
  • EC
  • InterPro Domains
    IPR029061 Thiamin diphosphate-binding fold
    IPR033248 Transketolase, C-terminal domain
    IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
    IPR005475 Transketolase-like, pyrimidine-binding domain
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145717, MGI:2145868
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory