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Diras2 Gene Detail
Summary
  • Symbol
    Diras2
  • Name
    DIRAS family, GTP-binding RAS-like 2
  • Synonyms
    2900052J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915453
    NCBI Gene: 68203
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:52658416-52685315 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 27.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    745 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915453
 protein coding gene Chr13:52658411-52685390 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020556
 protein coding gene Chr13:51778622-51807627 (-)
A/J MGP_AJ_G0020510
 protein coding gene Chr13:49929084-49955544 (-)
AKR/J MGP_AKRJ_G0020488
 protein coding gene Chr13:51351475-51379106 (-)
BALB/cJ MGP_BALBcJ_G0020506
 protein coding gene Chr13:50126388-50152847 (-)
C3H/HeJ MGP_C3HHeJ_G0020305
 protein coding gene Chr13:51186458-51214674 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020940
 protein coding gene Chr13:53379865-53407501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018522
 protein coding gene Chr13:47709113-47736650 (-)
CAST/EiJ MGP_CASTEiJ_G0019819
 protein coding gene Chr13:51178717-51211336 (-)
CBA/J MGP_CBAJ_G0020265
 protein coding gene Chr13:55390981-55418224 (-)
DBA/2J MGP_DBA2J_G0020388
 protein coding gene Chr13:49492793-49519164 (-)
FVB/NJ MGP_FVBNJ_G0020367
 protein coding gene Chr13:48932850-48960846 (-)
LP/J MGP_LPJ_G0020464
 protein coding gene Chr13:52056499-52083859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020396
 protein coding gene Chr13:54989070-55018169 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020983
 protein coding gene Chr13:50941920-50969393 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019881
 protein coding gene Chr13:51267348-51294930 (-)



Homology
more
  • Human Ortholog
    DIRAS2, DIRAS family GTPase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIRAS2, DIRAS family GTPase 2
  • Synonyms
    Di-Ras2
  • Links
    NCBI Gene ID: 54769
    UniProt: Q96HU8

  • Chr Location
    9q22.2; chr9:90609832-90642862 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In a pancreatic ductal adenocarcinoma model loss of expression increases tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    13
  • cDNA Data
    57
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047842 Ensembl Gene Model | MGI Sequence Detail 26900 C57BL/6J ±  kb
    transcript ENSMUST00000057442 Ensembl | MGI Sequence Detail 4786 Not Applicable  
    polypeptide ENSMUSP00000055416 Ensembl | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 59
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145227
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:348744 Chang Y, et al., The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Dev Cell. 2024 May 20;59(10):1317-1332.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory