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Sympk
Gene Detail
Symbol

Name
ID
Sympk
symplekin
MGI:1915438
Synonyms
1500016F02Rik, 4632415H16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19024377-19054618 bp, + strand
From VEGA annotation of GRCm38

  30242 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Sympk

Human
homologs
Human Homolog SYMPK, symplekin
NCBI Gene ID 8189
neXtProt AC  NX_Q92797
Human Synonyms  SPK, SYM
Human Chr (Location)  19q13.3; chr19:45815442-45863290 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous ofr a transgenic gene disruption exhibit anemia at E15 and hydrops fetalis.
 
Interactions
Sympk interacts with 33 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, mRNA polyadenylation, ...
Component cell junction, cytoplasm, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(133)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(133) cDNA(133)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022696 (Evidence)
Ensembl Gene ModelENSMUSG00000023118 (Evidence)
Entrez Gene68188 (Evidence)
UniGene130902
DFCITC1574048, TC1621421, TC1599412
DoTSDT.97341565, DT.97341491, DT.55281288, DT.101122893
NIA Mouse Gene IndexU007749
Consensus CDS ProjectCCDS52051.1
International Mouse Knockout Project StatusSympk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022696 VEGA Gene Model | MGI Sequence Detail 30242 C57BL/6J ±  kb
transcript OTTMUST00000054436 VEGA | MGI Sequence Detail 4116 Not Applicable 
polypeptide OTTMUSP00000025980 VEGA | MGI Sequence Detail 1288 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(10) UniProt(17)
Polymorphisms
SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR026003 HEAT repeat associated with sister chromatid cohesion protein
InterPro IPR021850 Protein of unknown function DUF3453
InterPro IPR022075 Symplekin C-terminal
Protein Ontology PR:000015869 symplekin
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:185949 Licatalosi DD, et al., Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
All references(40)
Other
accession IDs
MGI:1916246, MGI:2141800, MGI:2141965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory