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Sympk Gene Detail
Summary
  • Symbol
    Sympk
  • Name
    symplekin
  • Synonyms
    1500016F02Rik, 4632415H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915438
    NCBI Gene: 68188
Location & Maps
more
  • Sequence Map
    Chr7:19024377-19054618 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30242 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SYMPK, symplekin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SYMPK, symplekin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPK, SYM
  • Links
    NCBI Gene ID: 8189
    neXtProt AC: NX_Q92797

  • Chr Location
    19q13.3; chr19:45815442-45863290 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    9
  • Targeted
    1
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous ofr a transgenic gene disruption exhibit anemia at E15 and hydrops fetalis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022696 VEGA Gene Model | MGI Sequence Detail 30242 C57BL/6J ±  kb
transcript OTTMUST00000054436 VEGA | MGI Sequence Detail 4116 Not Applicable  
polypeptide OTTMUSP00000025980 VEGA | MGI Sequence Detail 1288 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    239 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 133
    cDNA 133

    Microarray probesets 3
Other
Accession IDs
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MGI:1916246, MGI:2141800, MGI:2141965
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:185949 Licatalosi DD, et al., Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory