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Coa4 Gene Detail
Summary
  • Symbol
    Coa4
  • Name
    cytochrome c oxidase assembly factor 4
  • Synonyms
    5330414O08Rik, Chchd8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915435
    NCBI Gene: 68185
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100537100-100540372 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915435
protein coding gene Chr7:100537071-100540372 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032572
protein coding gene Chr7:103428577-103431663 (+)
A/J MGP_AJ_G0032546
protein coding gene Chr7:100822005-100825091 (+)
AKR/J MGP_AKRJ_G0032482
protein coding gene Chr7:103223021-103226107 (+)
BALB/cJ MGP_BALBcJ_G0032557
protein coding gene Chr7:100504782-100507868 (+)
C3H/HeJ MGP_C3HHeJ_G0032272
protein coding gene Chr7:103598987-103602087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033055
protein coding gene Chr7:107357055-107360324 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030049
protein coding gene Chr7:103222148-103225188 (+)
CAST/EiJ MGP_CASTEiJ_G0031599
protein coding gene Chr7:95152028-95155138 (+)
CBA/J MGP_CBAJ_G0032239
protein coding gene Chr7:111041323-111044423 (+)
DBA/2J MGP_DBA2J_G0032390
protein coding gene Chr7:99153485-99156585 (+)
FVB/NJ MGP_FVBNJ_G0032347
protein coding gene Chr7:98938299-98941385 (+)
LP/J MGP_LPJ_G0032480
protein coding gene Chr7:104772883-104775969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032380
protein coding gene Chr7:112462659-112465935 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033077
protein coding gene Chr7:102488221-102493575 (+)
PWK/PhJ MGP_PWKPhJ_G0031317
protein coding gene Chr7:92269492-92272728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031160
protein coding gene Chr7:89797141-89800230 (+)
WSB/EiJ MGP_WSBEiJ_G0031716
protein coding gene Chr7:103188772-103192052 (+)



Homology
more
  • Human Ortholog
    COA4, cytochrome c oxidase assembly factor 4 homolog
  • Vertebrate Orthologs
    7
  • Human Ortholog
    COA4, cytochrome c oxidase assembly factor 4 homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHCHD8, CMC3, E2IG2
  • Links
    NCBI Gene ID: 51287
    neXtProt AC: NX_Q9NYJ1
    UniProt: Q9NYJ1

  • Chr Location
    11q13.4; chr11:73870258-73876901 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    58
  • Chemically induced (other)
    1
  • Gene trapped
    54
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Coa4
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68185 NCBI Gene Model | MGI Sequence Detail 3273 C57BL/6J ±  kb
transcript NM_183270 RefSeq | MGI Sequence Detail 834 C57BL/6  
polypeptide Q8BT51 UniProt | EBI | MGI Sequence Detail 87 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141868, MGI:2142187
References
more
  • Summaries
    All 37
    Gene Ontology 2
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory