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B230118H07Rik Gene Detail
Summary
  • Symbol
    B230118H07Rik
  • Name
    RIKEN cDNA B230118H07 gene
  • Synonyms
    NWC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915420
    NCBI Gene: 68170
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:101560781-101629332 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 53.83 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915420
 protein coding gene Chr2:101560781-101649532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026188
 protein coding gene Chr2:103430340-103520197 (-)
A/J MGP_AJ_G0026149
 protein coding gene Chr2:99156760-99247961 (-)
AKR/J MGP_AKRJ_G0026130
 protein coding gene Chr2:101856653-101950512 (-)
BALB/cJ MGP_BALBcJ_G0026158
 protein coding gene Chr2:99464576-99552092 (-)
C3H/HeJ MGP_C3HHeJ_G0025909
 protein coding gene Chr2:102224267-102317135 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026609
 protein coding gene Chr2:106931983-107025419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024000
 protein coding gene Chr2:94863476-94953466 (-)
CAST/EiJ MGP_CASTEiJ_G0025374
 protein coding gene Chr2:102640353-102734295 (-)
CBA/J MGP_CBAJ_G0025887
 protein coding gene Chr2:110611862-110715648 (-)
DBA/2J MGP_DBA2J_G0026023
 protein coding gene Chr2:98743486-98831651 (-)
FVB/NJ MGP_FVBNJ_G0025986
 protein coding gene Chr2:97746582-97833677 (-)
LP/J MGP_LPJ_G0026127
 protein coding gene Chr2:103590299-103679891 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026012
 protein coding gene Chr2:114601570-114694055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026663
 protein coding gene Chr2:102077805-102167866 (-)
PWK/PhJ MGP_PWKPhJ_G0025109
 protein coding gene Chr2:98212794-98307033 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024910
 protein coding gene Chr2:101278801-101377312 (-)
WSB/EiJ MGP_WSBEiJ_G0025441
 protein coding gene Chr2:102772053-102867685 (-)



Homology
more
  • Human Ortholog
    C11orf74, chromosome 11 open reading frame 74
  • Vertebrate Orthologs
    7
  • Human Ortholog
    C11orf74, chromosome 11 open reading frame 74
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEPIS, NWC
  • Links
    NCBI Gene ID: 119710
    neXtProt AC: NX_Q86VG3
    UniProt: Q86VG3

  • Chr Location
    11p12; chr11:36594245-36659291 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Homozygous deletion of one of two alternative first exons and its promoter has no obvious phenotypic effect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    11
  • Tissues
    7
  • cDNA Data
    57
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68170 NCBI Gene Model | MGI Sequence Detail 68552 C57BL/6J ±  kb
transcript NM_001362688 RefSeq | MGI Sequence Detail 2431 C57BL/6  
polypeptide Q9CQI4 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR040028 Uncharacterized protein C11orf74-like
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 6
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:268060 Majkowski M, et al., Lack of NWC protein (c11orf74 homolog) in murine spermatogenesis results in reduced sperm competitiveness and impaired ability to fertilize egg cells in vitro. PLoS One. 2018;13(12):e0208649
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory