Iftap MGI Mouse Gene Detail - MGI:1915420 - intraflagellar transport associated protein

Symbol

Iftap
Name

intraflagellar transport associated protein
Synonyms

B230118H07Rik, NWC

Feature Type

protein coding gene
IDs

MGI:1915420
NCBI Gene: 68170
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:101391124-101459376 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 53.83 cM, cytoband E2
Mapping Data

4 experiments

SNPs within 2kb

629 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915420	protein coding gene	Chr2:101391124-101479877 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026188	protein coding gene	Chr2:103430340-103520197 (-)
A/J	MGP_AJ_G0026149	protein coding gene	Chr2:99156760-99247961 (-)
AKR/J	MGP_AKRJ_G0026130	protein coding gene	Chr2:101856653-101950512 (-)
BALB/cJ	MGP_BALBcJ_G0026158	protein coding gene	Chr2:99464576-99552092 (-)
C3H/HeJ	MGP_C3HHeJ_G0025909	protein coding gene	Chr2:102224267-102317135 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026609	protein coding gene	Chr2:106931983-107025419 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024000	protein coding gene	Chr2:94863476-94953466 (-)
CAST/EiJ	MGP_CASTEiJ_G0025374	protein coding gene	Chr2:102640353-102734295 (-)
CBA/J	MGP_CBAJ_G0025887	protein coding gene	Chr2:110611862-110715648 (-)
DBA/2J	MGP_DBA2J_G0026023	protein coding gene	Chr2:98743486-98831651 (-)
FVB/NJ	MGP_FVBNJ_G0025986	protein coding gene	Chr2:97746582-97833677 (-)
LP/J	MGP_LPJ_G0026127	protein coding gene	Chr2:103590299-103679891 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026012	protein coding gene	Chr2:114601570-114694055 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026663	protein coding gene	Chr2:102077805-102167866 (-)
PWK/PhJ	MGP_PWKPhJ_G0025109	protein coding gene	Chr2:98212794-98307033 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024910	protein coding gene	Chr2:101278801-101377312 (-)
WSB/EiJ	MGP_WSBEiJ_G0025441	protein coding gene	Chr2:102772053-102867685 (-)

Human Ortholog

IFTAP, intraflagellar transport associated protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFTAP, intraflagellar transport associated protein
Synonyms

C11orf74, HEPIS, NWC
Links

HGNC:25142

NCBI Gene ID: 119710

neXtProt AC: NX_Q86VG3

UniProt: Q86VG3
Chr Location

11p12; chr11:36594245-36659291 (+) GRCh38.p7

Alliance of Genome Resources

Iftap stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: IFTAP
Gene Tree

Iftap

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Iftap
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are overtly normal and fertile under standard laboratory conditions. Under non-standard mating conditions, males show reduced sperm competitiveness, sperm head abnormalities, and reduced sperm ability to fertilize cumulus-intact eggs in vitro.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

683
Tissues

7
cDNA Data

57
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase iftap

ZFIN iftap

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Iftap interacts with 203 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

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All Sequences

64
RefSeq

6
UniProt

5
CCDS

CCDS16461.1, CCDS89525.1

Ensembl

ENSMUSG00000027165 (Evidence)
NCBI Gene

68170

			Length	Strain/Species	Flank
genomic	68170	NCBI Gene Model \| MGI Sequence Detail	68253	C57BL/6J	± kb
transcript	NM_001362688	RefSeq \| MGI Sequence Detail	2431	C57BL/6
polypeptide	Q9CQI4	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR040028 Intraflagellar transport-associated protein

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All nucleic 59

cDNA 59

Microarray probesets 6

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:303216 Takahara M, et al., C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization. J Biochem. 2019 Mar 1;165(3):257-267

TSS for Iftap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25363	Chr2:101459371-101459379 (-)	1 bp
Tssr25362	Chr2:101459361-101459370 (-)	10 bp
Tssr25361	Chr2:101459303-101459359 (-)	45 bp
Tssr25360	Chr2:101459275-101459299 (-)	89 bp
Tssr25359	Chr2:101454436-101454439 (-)	4,938 bp
Tssr25358	Chr2:101451378-101451411 (-)	7,981 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/18/2022 MGI 6.17