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Spire1 Gene Detail
Summary
  • Symbol
    Spire1
  • Name
    spire type actin nucleation factor 1
  • Synonyms
    6030430B19Rik, Spir-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915416
    NCBI Gene: 68166
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:67488209-67610790 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      122582 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPIRE1, spire type actin nucleation factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPIRE1, spire type actin nucleation factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Spir-1
  • Links
    NCBI Gene ID: 56907
    neXtProt AC: NX_Q08AE8
    UniProt: Q08AE8

  • Chr Location
    18p11.21; chr18:12446512-12658102 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with normal brain anatomy and intact visual and motor functions in both sexes, but show a male-specific increase in contextual and cued fear memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    60
  • Tissues
    38
  • cDNA Data
    120
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024533 Ensembl Gene Model | MGI Sequence Detail 122582 C57BL/6J ±  kb
transcript ENSMUST00000045105 Ensembl | MGI Sequence Detail 5033 Not Applicable  
polypeptide ENSMUSP00000049336 Ensembl | MGI Sequence Detail 643 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    880 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 122
    cDNA 120
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147220, MGI:2147317, MGI:2147372
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:226673 Pleiser S, et al., Enhanced fear expression in Spir-1 actin organizer mutant mice. Eur J Cell Biol. 2014 May-Jun;93(5-6):225-37
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2018
MGI 6.11 		The Jackson Laboratory