Spire1 MGI Mouse Gene Detail - MGI:1915416 - spire homolog 1 (Drosophila)

Spire1 Gene Detail

Symbol

Spire1
Name

spire homolog 1 (Drosophila)
Synonyms

6030430B19Rik, Spir-1

Feature Type

protein coding gene
IDs

MGI:1915416
NCBI Gene: 68166

Sequence Map

Chr18:67488209-67552777 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

64569 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 39.99 cM
Mapping Data

2 experiments

Human Ortholog

SPIRE1, spire type actin nucleation factor 1

Vertebrate Orthologs

9

Human Ortholog

SPIRE1, spire type actin nucleation factor 1
Orthology source: HomoloGene, HGNC
Synonyms

Spir-1
Links

HGNC:30622

NCBI Gene ID: 56907

neXtProt AC: NX_Q08AE8
Chr Location

18p11.21; chr18:12446512-12658102 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 35507
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SPIRE1
Protein SuperFamily

protein spire homolog
Gene Tree

Spire1

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Gene trapped

41
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele are viable and fertile with normal brain anatomy and intact visual and motor functions in both sexes, but show a male-specific increase in contextual and cued fear memory.

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All GO Annotations

26
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

60
Tissues

38
cDNA Data

120
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

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Spire1 interacts with 329 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

59
RefSeq

16
UniProt

4
CCDS

CCDS29323.1, CCDS37849.1
UniGene

208723

Ensembl

ENSMUSG00000024533 (Evidence)
NCBI Gene

68166

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024533	Ensembl Gene Model \| MGI Sequence Detail	64569	C57BL/6J	± kb
transcript	ENSMUST00000045105	Ensembl \| MGI Sequence Detail	5033	Not Applicable
polypeptide	ENSMUSP00000049336	Ensembl \| MGI Sequence Detail	643	Not Applicable

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SNPs within 2kb

880 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000015546 protein spire homolog 1
InterPro Domains

IPR011019 KIND domain

IPR029901 Protein Spire

IPR029905 Protein Spire1

IPR011011 Zinc finger, FYVE/PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 122

cDNA 120

Primer pair 2

Microarray probesets 6

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MGI:2147220, MGI:2147317, MGI:2147372

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:226673 Pleiser S, et al., Enhanced fear expression in Spir-1 actin organizer mutant mice. Eur J Cell Biol. 2014 May-Jun;93(5-6):225-37

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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