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Brk1
Gene Detail
 Symbol
Name
ID
Brk1
BRICK1, SCAR/WAVE actin-nucleating complex subunit
MGI:1915406
Synonyms 6720456B07Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
52.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:113604772-113616948 bp, + strand
From Ensembl annotation of GRCm38

  12177 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Brk1

Human
homologs
Human Homolog BRK1, BRICK1, SCAR/WAVE actin-nucleating complex subunit
NCBI Gene ID 55845
neXtProt AC  NX_Q8WUW1
Human Synonyms  C3orf10, hHBrk1, MDS027
Human Chr (Location)  3p25.3; chr3:10115649-10127190 (+)  GRCh38
Alleles
and
phenotypes
All alleles(27) : Gene trapped(26) Targeted(1)
 
Mice homozygous for disruptions in this gene display partial embryonic lethality before implantation with abnormalities in the actin network and failure of cultured embryos to hatch from the zona pellucida.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process actin cytoskeleton organization, cell motility, ...
Component cytoplasm, cytoskeleton, ...
Function protein complex binding, Rac GTPase binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (52)    Tissues (37)   
Theiler Stages: 9, 21, 22, 28
Assay TypeResults
RNA in situ 6
In situ reporter (knock in) 30
Northern blot 15
RT-PCR 1
cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000033940 (Evidence)
Entrez Gene101314 (Evidence)
UniGene485793
DFCITC1572405
DoTSDT.495093, DT.99862715
NIA Mouse Gene IndexU007276
Consensus CDS ProjectCCDS39595.1
International Mouse Knockout Project StatusBrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033940 Ensembl Gene Model | MGI Sequence Detail 12177 C57BL/6J ±  kb
transcript ENSMUST00000035725 Ensembl | MGI Sequence Detail 1092 Not Applicable 
polypeptide ENSMUSP00000041644 Ensembl | MGI Sequence Detail 75 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031049 protein BRICK1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:166082 Escobar B, et al., Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 2010 Nov 15;70(22):9349-59
All references(30)
Other
accession IDs
MGI:2141632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory