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Brk1 Gene Detail
Summary
  • Symbol
    Brk1
  • Name
    BRICK1, SCAR/WAVE actin-nucleating complex subunit
  • Synonyms
    6720456B07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915406
    NCBI Gene: 101314
  • Gene Overview
    MyGene.info: BRK1
Location & Maps
more
  • Sequence Map
    Chr6:113604772-113616951 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12180 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.81 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BRK1, BRICK1, SCAR/WAVE actin nucleating complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRK1, BRICK1, SCAR/WAVE actin nucleating complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3orf10, hHBrk1, HSPC300, MDS027
  • Links
    NCBI Gene ID: 55845
    neXtProt AC: NX_Q8WUW1

  • Chr Location
    3p25.3; chr3:10115649-10127190 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10210
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;2 macaque, rhesus
  • HCOP
    human homology predictions: BRK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    24
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Brk1
Mice homozygous for disruptions in this gene display partial embryonic lethality before implantation with abnormalities in the actin network and failure of cultured embryos to hatch from the zona pellucida.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056403 VEGA Gene Model | MGI Sequence Detail 12180 C57BL/6J ±  kb
transcript OTTMUST00000139356 VEGA | MGI Sequence Detail 1095 Not Applicable  
polypeptide OTTMUSP00000073129 VEGA | MGI Sequence Detail 75 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 99
    cDNA 98
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2141632
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:166082 Escobar B, et al., Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation. Cancer Res. 2010 Nov 15;70(22):9349-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory