Gtf2e2 MGI Mouse Gene Detail - MGI:1915403 - general transcription factor II E, polypeptide 2 (beta subunit)

Symbol

Gtf2e2
Name

general transcription factor II E, polypeptide 2 (beta subunit)
Synonyms

34kDa, C330006J08Rik

Feature Type

protein coding gene
IDs

MGI:1915403
NCBI Gene: 68153
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:34221942-34267201 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 20.79 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

1005 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915403	protein coding gene	Chr8:34221861-34267201 (+)
129S1/SvImJ	ENSMUSG00200021868	protein coding gene	Chr8:29280644-29325845 (+)
A/J	ENSMUSG00195004638	protein coding gene	Chr8:29796579-29841783 (+)
AKR/J	ENSMUSG00220024720	protein coding gene	Chr8:29559118-29604324 (+)
BALB/cJ	ENSMUSG00180005373	protein coding gene	Chr8:29339949-29385155 (+)
C3H/HeJ	ENSMUSG00175006343	protein coding gene	Chr8:29497516-29542717 (+)
C57BL/6NJ	ENSMUSG00215007481	protein coding gene	Chr8:29290154-29335494 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030968	protein coding gene	Chr8:27964354-28011220 (+)
CAST/EiJ	ENSTCUG00005021207	protein coding gene	Chr8:29472700-29517627 (+)
CBA/J	ENSMUSG00210013242	protein coding gene	Chr8:29325682-29370881 (+)
DBA/2J	ENSMUSG00185002007	protein coding gene	Chr8:35251952-35297151 (+)
FVB/NJ	ENSMUSG00205003255	protein coding gene	Chr8:28556146-28601494 (+)
JF1/MsJ	ENSUMUG00000007464	protein coding gene	Chr8:36965515-37010861 (+)
LP/J	ENSMUSG00230012488	protein coding gene	Chr8:38888107-38933308 (+)
NOD/ShiLtJ	ENSMUSG00190004205	protein coding gene	Chr8:29373096-29418300 (+)
NZO/HlLtJ	ENSMUSG00225014196	protein coding gene	Chr8:42503025-42548365 (+)
PWK/PhJ	ENSLUMG00010024297	protein coding gene	Chr8:29203653-29248649 (+)
SPRET/EiJ	ENSMSPG00010014892	protein coding gene	Chr8:29876328-29922701 (+)
WSB/EiJ	ENSIUOG00005009847	protein coding gene	Chr8:30116203-30161401 (+)

Human Ortholog

GTF2E2, general transcription factor IIE subunit 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GTF2E2, general transcription factor IIE subunit 2
Synonyms

FE, TF2E2, TFIIE-B, TTD6
Links

HGNC:4651

NCBI Gene ID: 2961

UniProt: P29084
Chr Location

8p12; chr8:30578318-30660846 (-) GRCh38

MGI Vertebrate Homology

Gtf2e2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GTF2E2
Protein SuperFamily

TFIIE-beta
Gene Tree

Gtf2e2

Diseases

1 with human GTF2E2 associations

				Human Disease	Mouse Models
				nonphotosensitive trichothiodystrophy 6 IDs nonphotosensitive trichothiodystrophy 6 DOID:0111872 OMIM:616943

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Gene trapped

33
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

677
Tissues

22
cDNA Data

15
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GTF2E2

Xenbase gtf2e2

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All Sequences

79
RefSeq

20
UniProt

6
CCDS

CCDS22236.1

Ensembl

ENSMUSG00000031585 (Evidence)
NCBI Gene

68153

			Length	Strain/Species	Flank
genomic	68153	NCBI Gene Model \| MGI Sequence Detail	45260	C57BL/6J	± kb
transcript	NM_001167922	RefSeq \| MGI Sequence Detail	1664	C57BL/6
polypeptide	Q9D902	UniProt \| EBI \| MGI Sequence Detail	292	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000029777 transcription initiation factor IIE subunit beta

(term hierarchy)
InterPro Domains

IPR040501 TFA2, Winged helix domain 2

IPR003166 Transcription factor TFIIE beta subunit, DNA-binding domain

IPR016656 Transcription initiation factor TFIIE, beta subunit

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 15

cDNA 15

Microarray probesets 4

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MGI:2142560

Summaries

All 50

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 12
Earliest

J:61657 De Graeve F, et al., A murine ATFa-associated factor with transcriptional repressing activity. Oncogene. 2000 Mar 30;19(14):1807-19
Latest

J:369747 Lin S, et al., Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice. Dev Cell. 2025 Jun 24;

TSS for Gtf2e2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76848	Chr8:34221895-34221974 (+)	-7 bp
Tssr76849	Chr8:34222077-34222165 (+)	179 bp
Tssr76850	Chr8:34222215-34222216 (+)	274 bp
Tssr76851	Chr8:34222224-34222264 (+)	302 bp
Tssr76852	Chr8:34222265-34222275 (+)	328 bp
Tssr76853	Chr8:34254886-34254914 (+)	32,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24