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Gtf2e2 Gene Detail
Summary
  • Symbol
    Gtf2e2
  • Name
    general transcription factor II E, polypeptide 2 (beta subunit)
  • Synonyms
    34kDa, C330006J08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915403
    NCBI Gene: 68153
  • Gene Overview
    MyGene.info: GTF2E2
Location & Maps
more
  • Sequence Map
    Chr8:33731833-33777164 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45332 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.79 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GTF2E2, general transcription factor IIE subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTF2E2, general transcription factor IIE subunit 2
    Orthology source: HomoloGene
  • Synonyms
    FE, TF2E2, TFIIE-B, TTD6
  • Links
    NCBI Gene ID: 2961
    neXtProt AC: NX_P29084

  • Chr Location
    8p12; chr8:30578514-30658241 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GTF2E2 associations

Human Disease Mouse Models
       Trichothiodystrophy 6, Nonphotosensitive; TTD6   OMIM: 616943
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Gene trapped
    47
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049715 VEGA Gene Model | MGI Sequence Detail 45332 C57BL/6J ±  kb
transcript OTTMUST00000126635 VEGA | MGI Sequence Detail 1566 Not Applicable  
polypeptide OTTMUSP00000068453 VEGA | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    212 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029777 transcription initiation factor IIE subunit beta
  • InterPro Domains
    IPR003166 Transcription factor TFIIE beta subunit, DNA-binding domain
    IPR016656 Transcription initiation factor TFIIE, beta subunit
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142560
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228779 Alpern D, et al., TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Elife. 2014;3:e03613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory