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Gtf2e2 Gene Detail
Summary
  • Symbol
    Gtf2e2
  • Name
    general transcription factor II E, polypeptide 2 (beta subunit)
  • Synonyms
    34kDa, C330006J08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915403
    NCBI Gene: 68153
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34221942-34267201 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.79 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915403
protein coding gene Chr8:34221861-34267201 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033527
protein coding gene Chr8:32190097-32243566 (+)
A/J MGP_AJ_G0033507
protein coding gene Chr8:30961293-31006735 (+)
AKR/J MGP_AKRJ_G0033431
protein coding gene Chr8:31927996-31977502 (+)
BALB/cJ MGP_BALBcJ_G0033503
protein coding gene Chr8:31082655-31127940 (+)
C3H/HeJ MGP_C3HHeJ_G0033215
protein coding gene Chr8:32252517-32300409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034019
protein coding gene Chr8:33431017-33479182 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030968
protein coding gene Chr8:27964354-28011220 (+)
CAST/EiJ MGP_CASTEiJ_G0032542
protein coding gene Chr8:31693013-31742402 (+)
CBA/J MGP_CBAJ_G0033193
protein coding gene Chr8:34736845-34792298 (+)
DBA/2J MGP_DBA2J_G0033346
protein coding gene Chr8:30939639-30984712 (+)
FVB/NJ MGP_FVBNJ_G0033291
protein coding gene Chr8:30603310-30648715 (+)
LP/J MGP_LPJ_G0033436
protein coding gene Chr8:32156354-32207322 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033333
protein coding gene Chr8:34271408-34321858 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034038
protein coding gene Chr8:32018400-32066392 (+)
PWK/PhJ MGP_PWKPhJ_G0032254
protein coding gene Chr8:30456049-30501622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032085
protein coding gene Chr8:31283857-31331531 (+)
WSB/EiJ MGP_WSBEiJ_G0032658
protein coding gene Chr8:32150401-32201370 (+)



Homology
more
  • Human Ortholog
    GTF2E2, general transcription factor IIE subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2E2, general transcription factor IIE subunit 2
  • Synonyms
    FE, TF2E2, TFIIE-B, TTD6
  • Links
    NCBI Gene ID: 2961
    neXtProt AC: NX_P29084
    UniProt: P29084

  • Chr Location
    8p12; chr8:30578318-30658236 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human GTF2E2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68153 NCBI Gene Model | MGI Sequence Detail 45260 C57BL/6J ±  kb
    transcript NM_001167922 RefSeq | MGI Sequence Detail 1664 C57BL/6  
    polypeptide Q9D902 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000029777 transcription initiation factor IIE subunit beta
    • InterPro Domains
      IPR040501 TFA2, Winged helix domain 2
      IPR003166 Transcription factor TFIIE beta subunit, DNA-binding domain
      IPR016656 Transcription initiation factor TFIIE, beta subunit
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142560
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:61657 De Graeve F, et al., A murine ATFa-associated factor with transcriptional repressing activity. Oncogene. 2000 Mar 30;19(14):1807-19
    • Latest
      J:228779 Alpern D, et al., TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Elife. 2014;3:e03613

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory