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Otub2
Gene Detail
Symbol

Name
ID
Otub2
OTU domain, ubiquitin aldehyde binding 2
MGI:1915399
Synonyms
2010015L18Rik, 4930586I02Rik, OTB2, OTU2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
52.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:103388682-103406345 bp, + strand
From VEGA annotation of GRCm38

  17664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: OTUB2
Protein SuperFamily: ubiquitin thioesterase Otubain
Gene Tree: Otub2

Human
homologs
OTUB2, OTU deubiquitinase, ubiquitin aldehyde binding 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 78990
neXtProt AC: NX_Q96DC9

Human Synonyms: C14orf137, OTB2, OTU2

Human Chr (Location): 14q32.12; chr14:94016095-94048930 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
Interactions
Otub2 interacts with 232 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process protein deubiquitination, protein K11-linked deubiquitination, ...
Component nucleus
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase otub2    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023000 (Evidence)
Ensembl Gene Model ENSMUSG00000021203 (Evidence)
Entrez Gene 68149 (Evidence)
DFCI TC1577943, TC1605775
DoTS DT.91423568, DT.91340101, DT.101210308, DT.101379337, DT.526661, DT.101122037, DT.94190279
NIA Mouse Gene Index U014315
EC 3.4.19.12
Consensus CDS Project CCDS36528.1, CCDS49150.1
International Mouse Phenotyping Consortium Status Otub2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023000 VEGA Gene Model | MGI Sequence Detail 17664 C57BL/6J ±  kb
transcript OTTMUST00000055398 VEGA | MGI Sequence Detail 3228 Not Applicable 
polypeptide OTTMUSP00000026530 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003323 Ovarian tumour, otubain
InterPro IPR019400 Peptidase C65, otubain
InterPro IPR016615 Ubiquitin thioesterase Otubain
Protein Ontology PR:000012081 ubiquitin thioesterase OTUB2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)
Other
accession IDs
MGI:1919646, MGI:2144803, MGI:2145047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory