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Arl13b Gene Detail
Summary
  • Symbol
    Arl13b
  • Name
    ADP-ribosylation factor-like 13B
  • Synonyms
    A530097K21Rik, A930014M17Rik, Arl2l1, C530009C10Rik, hnn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915396
    NCBI Gene: 68146
  • Gene Overview
    MyGene.info: ARL13B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:62793685-62847040 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53356 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 36.43 cM, cytoband C1.2
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ARL13B, ADP ribosylation factor like GTPase 13B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARL13B, ADP ribosylation factor like GTPase 13B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARL2L1, JBTS8
  • Links
    NCBI Gene ID: 200894
    neXtProt AC: NX_Q3SXY8
    UniProt: Q3SXY8

  • Chr Location
    3q11.1-q11.2; chr3:93980139-94055678 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ARL13B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation die at E13-E14 exhibiting left-right randomization and absence of the floor plate in the caudal spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024090 VEGA Gene Model | MGI Sequence Detail 53356 C57BL/6J ±  kb
    transcript OTTMUST00000058920 VEGA | MGI Sequence Detail 3528 Not Applicable  
    polypeptide OTTMUSP00000028614 VEGA | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      280 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004277 ADP-ribosylation factor-like protein 13B
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR006689 Small GTPase superfamily, ARF/SAR type
      IPR024156 Small GTPase superfamily, ARF type
      IPR005225 Small GTP-binding protein domain
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925200, MGI:3026930, MGI:3578137
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 89
      Gene Ontology 17
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:262122 Gigante ED, et al., Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response. Dev Biol. 2018 May 15;437(2):152-162

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory