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Ino80 Gene Detail
Summary
  • Symbol
    Ino80
  • Name
    INO80 complex subunit
  • Synonyms
    2310079N15Rik, 4632409L19Rik, INO80, Inoc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915392
    NCBI Gene: 68142
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119373042-119477629 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.97 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    750 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915392
protein coding gene Chr2:119373042-119477687 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026343
protein coding gene Chr2:122133971-122239911 (-)
A/J MGP_AJ_G0026304
protein coding gene Chr2:117157039-117267545 (-)
AKR/J MGP_AKRJ_G0026283
protein coding gene Chr2:120437368-120543059 (-)
BALB/cJ MGP_BALBcJ_G0026317
protein coding gene Chr2:117415122-117519344 (-)
C3H/HeJ MGP_C3HHeJ_G0026063
protein coding gene Chr2:120897797-121009752 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026764
protein coding gene Chr2:126146898-126257594 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024144
protein coding gene Chr2:112206903-112310481 (-)
CAST/EiJ MGP_CASTEiJ_G0025525
protein coding gene Chr2:121209004-121327691 (-)
CBA/J MGP_CBAJ_G0026039
protein coding gene Chr2:130574921-130697903 (-)
DBA/2J MGP_DBA2J_G0026178
protein coding gene Chr2:116575104-116679056 (-)
FVB/NJ MGP_FVBNJ_G0026140
protein coding gene Chr2:115396634-115501719 (-)
LP/J MGP_LPJ_G0026279
protein coding gene Chr2:122443093-122551922 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026159
protein coding gene Chr2:134920844-135029450 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026819
protein coding gene Chr2:120553836-120659820 (-)
PWK/PhJ MGP_PWKPhJ_G0025261
protein coding gene Chr2:116139321-116248253 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025060
protein coding gene Chr2:119744217-119854873 (-)
WSB/EiJ MGP_WSBEiJ_G0025594
protein coding gene Chr2:121393088-121501584 (-)



Homology
more
  • Human Ortholog
    INO80, INO80 complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    INO80, INO80 complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INO80A, INOC1
  • Links
    NCBI Gene ID: 54617
    neXtProt AC: NX_Q9ULG1
    UniProt: Q9ULG1

  • Chr Location
    15q15.1; chr15:40978880-41117081 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75070
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: INO80
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 6 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele die around E7.5 and show absence of anterior and distal visceral endoderm. Another null allele results in embryonic lethality by E13.5-E14.5 with severe growth retardation and developmental defects. Heterozygotes show defects in hindlimb extension reflex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68142 NCBI Gene Model | MGI Sequence Detail 104588 C57BL/6J ±  kb
    transcript NM_026574 RefSeq | MGI Sequence Detail 6354 C57BL/6  
    polypeptide Q6ZPV2 UniProt | EBI | MGI Sequence Detail 1559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 104
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923726
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:255744 Rhee S, et al., Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nat Commun. 2018 Jan 25;9(1):368

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory