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Upf3b Gene Detail
Summary
  • Symbol
    Upf3b
  • Name
    UPF3 regulator of nonsense transcripts homolog B (yeast)
  • Synonyms
    5730594O13Rik, RENT3B, UPF3X
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915384
    NCBI Gene: 68134
  • Gene Overview
    MyGene.info: UPF3B
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:37091678-37110322 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18645 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 21.51 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    UPF3B, UPF3B, regulator of nonsense mediated mRNA decay
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UPF3B, UPF3B, regulator of nonsense mediated mRNA decay
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUPF3B, MRX62, MRXS14, RENT3B, UPF3BP1, UPF3BP2, UPF3BP3, Upf3p-X, UPF3X
  • Links
    NCBI Gene ID: 65109
    neXtProt AC: NX_Q9BZI7
    UniProt: Q9BZI7

  • Chr Location
    Xq24; chrX:119805311-119853028 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human UPF3B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for a null mutation display impaired startle responses, prepulse inhibition, and cued and contextual fear conditioning behavior, limb grasping, decreased neuronal precursor proliferation, and increased neuronal precursor proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017109 VEGA Gene Model | MGI Sequence Detail 18645 C57BL/6J ±  kb
transcript OTTMUST00000041431 VEGA | MGI Sequence Detail 2344 Not Applicable  
polypeptide OTTMUSP00000018591 VEGA | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR034979 UPF3B, RNA recognition motif-like domain
    IPR005120 UPF3 domain
Molecular
Reagents
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  • All nucleic 50
    cDNA 46
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
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MGI:2147871, MGI:2148018
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:253157 Huang L, et al., A Upf3b-mutant mouse model with behavioral and neurogenesis defects. Mol Psychiatry. 2017 Sep 26;None(None):None

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory