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Gcsh Gene Detail
Summary
  • Symbol
    Gcsh
  • Name
    glycine cleavage system protein H (aminomethyl carrier)
  • Synonyms
    1100001L02Rik, 5730591C18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915383
    NCBI Gene: 68133
  • Gene Overview
    MyGene.info: GCSH
Location & Maps
more
  • Sequence Map
    Chr8:116981810-116993537 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11728 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 63.43 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GCSH, glycine cleavage system protein H
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GCSH, glycine cleavage system protein H
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCE, NKH
  • Links
    NCBI Gene ID: 2653
    neXtProt AC: NX_P23434

  • Chr Location
    16q23.2; chr16:81081947-81096375 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GCSH associations

Human Disease Mouse Models
       Glycine Encephalopathy; GCE   OMIM: 605899
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    11
  • Gene trapped
    7
  • Targeted
    4
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027530 VEGA Gene Model | MGI Sequence Detail 11728 C57BL/6J ±  kb
transcript OTTMUST00000068151 VEGA | MGI Sequence Detail 1443 Not Applicable  
polypeptide OTTMUSP00000034396 VEGA | MGI Sequence Detail 170 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 98

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915663
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory