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Gcsh
Gene Detail
Symbol

Name
ID
Gcsh
glycine cleavage system protein H (aminomethyl carrier)
MGI:1915383
Synonyms
1100001L02Rik, 5730591C18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
63.43 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:116981810-116993537 bp, - strand
From VEGA annotation of GRCm38

  11728 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:90880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GCSH
Gene Tree: Gcsh

Human
homologs
GCSH, glycine cleavage system protein H (aminomethyl carrier)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2653
neXtProt AC: NX_P23434

Human Synonyms: GCE, NKH

Human Chr (Location): 16q23.2; chr16:81081947-81096375 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GCSH

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(4)
Incidental mutations (data from APF )
Interactions
Gcsh interacts with 124 markers (Mir7-1, Mir16-1, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (221)    Tissues (146)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 221
cDNA source data(98)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gcsh    NEW 
Molecular
reagents
All nucleic(98) cDNA(98)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027530 (Evidence)
Ensembl Gene Model ENSMUSG00000034424 (Evidence)
Entrez Gene 68133 (Evidence)
UniGene 258462
DFCI TC1575069
DoTS DT.536460, DT.91345185, DT.94271452
NIA Mouse Gene Index U030302, U059278
PDB 2EDG
Consensus CDS Project CCDS22696.1
International Mouse Phenotyping Consortium Status Gcsh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027530 VEGA Gene Model | MGI Sequence Detail 11728 C57BL/6J ±  kb
transcript OTTMUST00000068151 VEGA | MGI Sequence Detail 1443 Not Applicable 
polypeptide OTTMUSP00000034396 VEGA | MGI Sequence Detail 170 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR002930 Glycine cleavage H-protein
InterPro IPR017453 Glycine cleavage H-protein, subgroup
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000007909 glycine cleavage system H protein, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:1915663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory