Rchy1
Gene Detail

Symbol

Name
ID

Rchy1
ring finger and CHY zinc finger domain containing 1
MGI:1915348

Synonyms

6720407C15Rik, Pirh2, PRO1996, Zfp363

Feature Type

protein coding gene

Genetic Map

Chromosome 5
45.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:91948904-91963068 bp, - strand From VEGA annotation of GRCm38   14165 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:22894  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rchy1

Human
homologs

Human Homolog		RCHY1, ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
NCBI Gene ID		25898
neXtProt AC		NX_Q96PM5
Human Synonyms		ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
Human Chr (Location)		4q21.1; chr4:75479037-75514674 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mouse embryonic fibroblasts from mice homozygous for a knock-out allele exhibit decreased cellular sensitivity to UV irradiation.

 

Interactions

Rchy1 interacts with 104 markers (Mir10a, Mir10b, Mir16-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (26 annotations)

Process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, ...
Component	cytoplasm, nucleoplasm, ...
Function	coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(9) cDNA(9)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000020371 (Evidence)
Ensembl Gene Model	ENSMUSG00000029397 (Evidence)
Entrez Gene	68098 (Evidence)
DFCI	TC1600271, TC1575916, TC1695402
NIA Mouse Gene Index	U026398
EC	6.3.2.-
PDB	2ECM, 2DKT
Consensus CDS Project	CCDS19424.1, CCDS71613.1
International Mouse Knockout Project Status	Rchy1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020371	VEGA Gene Model | MGI Sequence Detail	14165	C57BL/6J
transcript	OTTMUST00000048310	VEGA | MGI Sequence Detail	1967	Not Applicable
polypeptide	OTTMUSP00000022111	VEGA | MGI Sequence Detail	261	Not Applicable

All sequences(45) RefSeq(7) UniProt(5)

Polymorphisms

SNPs within 2kb(117 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004039	Rubredoxin-type fold
InterPro	IPR008913	Zinc finger, CHY-type
InterPro	IPR017921	Zinc finger, CTCHY-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000029894	RING finger and CHY zinc finger domain-containing protein 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:197270 Jung YS, et al., Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Invest Dermatol. 2013 May;133(5):1178-87
All references(37)

Other
accession IDs

MGI:2141088