Rchy1 MGI Mouse Gene Detail - MGI:1915348 - ring finger and CHY zinc finger domain containing 1

Symbol

Rchy1
Name

ring finger and CHY zinc finger domain containing 1
Synonyms

6720407C15Rik, Pirh2, PRO1996, Zfp363

Feature Type

protein coding gene
IDs

MGI:1915348
NCBI Gene: 68098
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:92096763-92110927 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 45.58 cM
Mapping Data

2 experiments

SNPs within 2kb

705 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915348	protein coding gene	Chr5:92096701-92110988 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029739	protein coding gene	Chr5:93080744-93096204 (-)
A/J	MGP_AJ_G0029705	protein coding gene	Chr5:89406737-89420884 (-)
AKR/J	MGP_AKRJ_G0029651	protein coding gene	Chr5:92324715-92339212 (-)
BALB/cJ	MGP_BALBcJ_G0029715	protein coding gene	Chr5:90290338-90304985 (-)
C3H/HeJ	MGP_C3HHeJ_G0029438	protein coding gene	Chr5:92728842-92745213 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030169	protein coding gene	Chr5:96797435-96815239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027405	protein coding gene	Chr5:85056555-85071671 (-)
CAST/EiJ	MGP_CASTEiJ_G0028848	protein coding gene	Chr5:92103976-92118424 (-)
CBA/J	MGP_CBAJ_G0029408	protein coding gene	Chr5:100127073-100145685 (-)
DBA/2J	MGP_DBA2J_G0029552	protein coding gene	Chr5:89451631-89466325 (-)
FVB/NJ	MGP_FVBNJ_G0029511	protein coding gene	Chr5:88303351-88317947 (-)
LP/J	MGP_LPJ_G0029640	protein coding gene	Chr5:93465325-93480737 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029540	protein coding gene	Chr5:105077157-105092230 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030203	protein coding gene	Chr5:91857203-91874128 (-)
PWK/PhJ	MGP_PWKPhJ_G0028567	protein coding gene	Chr5:88509775-88524479 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028402	protein coding gene	Chr5:91215565-91229714 (-)
WSB/EiJ	MGP_WSBEiJ_G0028927	protein coding gene	Chr5:92313408-92328910 (-)

Human Ortholog

RCHY1, ring finger and CHY zinc finger domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCHY1, ring finger and CHY zinc finger domain containing 1
Synonyms

ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
Links

HGNC:17479

NCBI Gene ID: 25898

UniProt: Q96PM5
Chr Location

4q21.1; chr4:75479033-75514764 (-) GRCh38

MGI Vertebrate Homology

Rchy1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCHY1
Gene Tree

Rchy1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

7
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Rchy1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Mouse embryonic fibroblasts from mice homozygous for a knock-out allele exhibit decreased cellular sensitivity to UV irradiation.

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All GO Annotations

55
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rchy1

ZFIN rchy1

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All Sequences

51
RefSeq

7
UniProt

3
CCDS

CCDS19424.1, CCDS71613.1

Ensembl

ENSMUSG00000029397 (Evidence)
NCBI Gene

68098

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029397	Ensembl Gene Model \| MGI Sequence Detail	14165	C57BL/6J	± kb
transcript	ENSMUST00000031345	Ensembl \| MGI Sequence Detail	1967	Not Applicable
polypeptide	ENSMUSP00000031345	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029894 RING finger and CHY zinc finger domain-containing protein 1

(term hierarchy)
PDB

2DKT, 2ECM
EC

2.3.2.27
InterPro Domains

IPR039512 RCHY1, zinc-ribbon

IPR008913 Zinc finger, CHY-type

IPR037274 Zinc finger, CHY-type superfamily

IPR017921 Zinc finger, CTCHY-type

IPR037275 Zinc finger, CTCHY-type superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 10

cDNA 10

Microarray probesets 2

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MGI:2141088

Summaries

All 48

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:228256 Bohgaki M, et al., The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. Cell Death Differ. 2013 Jun;20(6):812-22

TSS for Rchy1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51835	Chr5:92110965-92110996 (-)	-54 bp
Tssr51834	Chr5:92110939-92110964 (-)	-25 bp
Tssr51833	Chr5:92110698-92110746 (-)	205 bp
Tssr51832	Chr5:92110574-92110599 (-)	340 bp
Tssr51831	Chr5:92110174-92110183 (-)	748 bp
Tssr51830	Chr5:92110141-92110152 (-)	780 bp
Tssr51829	Chr5:92109466-92109471 (-)	1,458 bp
Tssr51828	Chr5:92109306-92109321 (-)	1,613 bp
Tssr51827	Chr5:92097472-92097483 (-)	13,449 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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