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Eef1akmt1 Gene Detail
Summary
  • Symbol
    Eef1akmt1
  • Name
    eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
  • Synonyms
    2510005D08Rik, Ayu21-96, GtAyu21-96, Gt(Ayu21)96Imeg, N6amt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915293
    NCBI Gene: 68043
Location & Maps
more
  • Sequence Map
    Chr14:57549598-57571569 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21972 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 30.10 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EEF1AKMT1, eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EEF1AKMT1, eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ESP13, N6AMT2
  • Links
    NCBI Gene ID: 221143
    neXtProt AC: NX_Q8WVE0

  • Chr Location
    13q12.11; chr13:20728931-20773956 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Gene trapped
    34
  • Targeted
    2
  • Genomic Mutations
    1 involving Eef1akmt1
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021951 Ensembl Gene Model | MGI Sequence Detail 21972 C57BL/6J ±  kb
transcript ENSMUST00000022518 Ensembl | MGI Sequence Detail 836 Not Applicable  
polypeptide ENSMUSP00000022518 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010943 N(6)-adenine-specific DNA methyltransferase 2
  • EC
  • InterPro Domains
    IPR002052 DNA methylase, N-6 adenine-specific, conserved site
    IPR019369 Protein-lysine N-methyltransferase Efm5
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145784, MGI:3629757
References
more
  • Summaries
    All 33
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory