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Nmb Gene Detail
Summary
  • Symbol
    Nmb
  • Name
    neuromedin B
  • Synonyms
    3110023K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915289
    NCBI Gene: 68039
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80902227-80905076 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.71 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915289
protein coding gene Chr7:80902227-80913681 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032421
protein coding gene Chr7:82912186-82915027 (-)
A/J MGP_AJ_G0032400
protein coding gene Chr7:80964536-80967373 (-)
AKR/J MGP_AKRJ_G0032336
protein coding gene Chr7:82732389-82735226 (-)
BALB/cJ MGP_BALBcJ_G0032412
protein coding gene Chr7:80634191-80637018 (-)
C3H/HeJ MGP_C3HHeJ_G0032125
protein coding gene Chr7:83372679-83375526 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032904
protein coding gene Chr7:86159851-86163011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029912
protein coding gene Chr7:83470813-83473657 (-)
CAST/EiJ MGP_CASTEiJ_G0031453
protein coding gene Chr7:74276316-74279157 (-)
CBA/J MGP_CBAJ_G0032091
protein coding gene Chr7:89029894-89032754 (-)
DBA/2J MGP_DBA2J_G0032246
protein coding gene Chr7:79511596-79514423 (-)
FVB/NJ MGP_FVBNJ_G0032201
protein coding gene Chr7:79446095-79448920 (-)
LP/J MGP_LPJ_G0032327
protein coding gene Chr7:84152881-84155706 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032238
protein coding gene Chr7:89152233-89155070 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032922
protein coding gene Chr7:82168566-82171406 (-)
PWK/PhJ MGP_PWKPhJ_G0031173
protein coding gene Chr7:72716249-72719096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031014
protein coding gene Chr7:69186099-69188585 (-)
WSB/EiJ MGP_WSBEiJ_G0031571
protein coding gene Chr7:82527025-82529846 (-)



Homology
more
  • Human Ortholog
    NMB, neuromedin B
  • Vertebrate Orthologs
    6
  • Human Ortholog
    NMB, neuromedin B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4828
    neXtProt AC: NX_P08949
    UniProt: P08949

  • Chr Location
    15q25.2; chr15:84655129-84658611 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Nmb
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knockout allele exhibit attenuated scratching in response to histamine, compound 48/80 and 5-HT.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025723 Ensembl Gene Model | MGI Sequence Detail 2850 C57BL/6J ±  kb
transcript ENSMUST00000119428 Ensembl | MGI Sequence Detail 678 Not Applicable  
polypeptide ENSMUSP00000113407 Ensembl | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000874 Bombesin/neuromedin-B/ranatensin peptide family
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:253572 Wan L, et al., Distinct roles of NMB and GRP in itch transmission. Sci Rep. 2017 Nov 13;7(1):15466

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory