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Emc4 Gene Detail
Summary
  • Symbol
    Emc4
  • Name
    ER membrane protein complex subunit 4
  • Synonyms
    2610318K02Rik, Tmem85
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915282
    NCBI Gene: 68032
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:112363019-112368027 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.02 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915282
protein coding gene Chr2:112363011-112368027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026289
protein coding gene Chr2:114810321-114815348 (-)
A/J MGP_AJ_G0026250
protein coding gene Chr2:110103666-110109352 (-)
AKR/J MGP_AKRJ_G0026229
protein coding gene Chr2:113191310-113196436 (-)
BALB/cJ MGP_BALBcJ_G0026263
protein coding gene Chr2:110370222-110375346 (-)
C3H/HeJ MGP_C3HHeJ_G0026008
protein coding gene Chr2:113592013-113599011 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026710
protein coding gene Chr2:118614604-118619620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024090
protein coding gene Chr2:105343561-105348663 (-)
CAST/EiJ MGP_CASTEiJ_G0025471
protein coding gene Chr2:113864178-113880039 (-)
CBA/J MGP_CBAJ_G0025985
protein coding gene Chr2:122745927-122750954 (-)
DBA/2J MGP_DBA2J_G0026124
protein coding gene Chr2:109567423-109572450 (-)
FVB/NJ MGP_FVBNJ_G0026086
protein coding gene Chr2:108445625-108461859 (-)
LP/J MGP_LPJ_G0026225
protein coding gene Chr2:115090946-115109282 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026105
protein coding gene Chr2:127153608-127158682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026765
protein coding gene Chr2:113263686-113268702 (-)
PWK/PhJ MGP_PWKPhJ_G0025207
protein coding gene Chr2:109069021-109074268 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025006
protein coding gene Chr2:112455829-112460866 (-)
WSB/EiJ MGP_WSBEiJ_G0025540
protein coding gene Chr2:114070117-114089486 (-)



Homology
more
  • Human Ortholog
    EMC4, ER membrane protein complex subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMC4, ER membrane protein complex subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PIG17, TMEM85
  • Links
    NCBI Gene ID: 51234
    neXtProt AC: NX_Q5J8M3
    UniProt: Q5J8M3

  • Chr Location
    15q14; chr15:34224997-34230165 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Emc4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68032 NCBI Gene Model | MGI Sequence Detail 5009 C57BL/6J ±  kb
transcript NM_026519 RefSeq | MGI Sequence Detail 975 C57BL/6  
polypeptide Q9CZX9 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:265020 Tang X, et al., EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory