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Emc4 Gene Detail
Summary
  • Symbol
    Emc4
  • Name
    ER membrane protein complex subunit 4
  • Synonyms
    2610318K02Rik, Tmem85
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915282
    NCBI Gene: 68032
Location & Maps
more
  • Sequence Map
    Chr2:112363011-112368027 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5017 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.02 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EMC4, ER membrane protein complex subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EMC4, ER membrane protein complex subunit 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PIG17, TMEM85
  • Links
    NCBI Gene ID: 51234
    neXtProt AC: NX_Q5J8M3

  • Chr Location
    15q14; chr15:34224997-34230165 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Emc4
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015140 VEGA Gene Model | MGI Sequence Detail 5017 C57BL/6J ±  kb
transcript OTTMUST00000035913 VEGA | MGI Sequence Detail 983 Not Applicable  
polypeptide OTTMUSP00000016120 VEGA | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    25 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000029447 ER membrane protein complex subunit 4
  • InterPro Domains
    IPR009445 Protein of unknown function DUF1077, TMEM85
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory