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Pclaf Gene Detail
Summary
  • Symbol
    Pclaf
  • Name
    PCNA clamp associated factor
  • Synonyms
    2810417H13Rik, mKIAA0101, p15(PAF)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915276
    NCBI Gene: 68026
  • Gene Overview
    MyGene.info: PCLAF
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65890237-65903266 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915276
protein coding gene Chr9:65890237-65903551 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034968
protein coding gene Chr9:65686666-65700996 (+)
A/J MGP_AJ_G0034948
protein coding gene Chr9:63443679-63456442 (+)
AKR/J MGP_AKRJ_G0034878
protein coding gene Chr9:64956172-64970189 (+)
BALB/cJ MGP_BALBcJ_G0034941
protein coding gene Chr9:63159267-63172623 (+)
C3H/HeJ MGP_C3HHeJ_G0034651
protein coding gene Chr9:65483737-65498312 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035460
protein coding gene Chr9:67465538-67481336 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032371
protein coding gene Chr9:63085518-63102286 (+)
CAST/EiJ MGP_CASTEiJ_G0033972
protein coding gene Chr9:65673648-65688169 (+)
CBA/J MGP_CBAJ_G0034622
protein coding gene Chr9:69820970-69824470 (+)
DBA/2J MGP_DBA2J_G0034781
protein coding gene Chr9:63214475-63229629 (+)
FVB/NJ MGP_FVBNJ_G0034723
protein coding gene Chr9:62552341-62566067 (+)
LP/J MGP_LPJ_G0034864
protein coding gene Chr9:65927158-65941840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034765
protein coding gene Chr9:71072098-71086360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035482
protein coding gene Chr9:65064978-65080679 (+)
PWK/PhJ MGP_PWKPhJ_G0033676
protein coding gene Chr9:63415562-63428548 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033510
protein coding gene Chr9:65340928-65353113 (+)
WSB/EiJ MGP_WSBEiJ_G0034085
protein coding gene Chr9:64954379-64967087 (+)



Homology
more
  • Human Ortholog
    PCLAF, PCNA clamp associated factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PCLAF, PCNA clamp associated factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIAA0101, L5, NS5ATP9, OEATC, OEATC1, OEATC-1, p15PAF, p15/PAF, p15(PAF), PAF, PAF15
  • Links
    NCBI Gene ID: 9768
    neXtProt AC: NX_Q15004
    UniProt: Q15004

  • Chr Location
    15q22.31; chr15:64364994-64387687 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired hematopoietic stem cell function and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040204 Ensembl Gene Model | MGI Sequence Detail 13030 C57BL/6J ±  kb
    transcript ENSMUST00000045802 Ensembl | MGI Sequence Detail 2188 Not Applicable  
    polypeptide ENSMUSP00000038877 Ensembl | MGI Sequence Detail 110 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147825
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory