About   Help   FAQ
Med8 Gene Detail
Summary
  • Symbol
    Med8
  • Name
    mediator complex subunit 8
  • Synonyms
    2210021A15Rik, ARC32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915269
    NCBI Gene: 80509
  • Gene Overview
    MyGene.info: MED8
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118409337-118415782 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 54.61 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915269
protein coding gene Chr4:118409298-118415824 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028666
protein coding gene Chr4:119466442-119472870 (+)
A/J MGP_AJ_G0028627
protein coding gene Chr4:114831690-114838105 (+)
AKR/J MGP_AKRJ_G0028577
protein coding gene Chr4:117335724-117342169 (+)
BALB/cJ MGP_BALBcJ_G0028648
protein coding gene Chr4:115472534-115478945 (+)
C3H/HeJ MGP_C3HHeJ_G0028362
protein coding gene Chr4:118915396-118921805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029089
protein coding gene Chr4:124029452-124035904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026373
protein coding gene Chr4:108851005-108857393 (+)
CAST/EiJ MGP_CASTEiJ_G0027796
protein coding gene Chr4:116170957-116180551 (+)
CBA/J MGP_CBAJ_G0028329
protein coding gene Chr4:127434087-127440490 (+)
DBA/2J MGP_DBA2J_G0028477
protein coding gene Chr4:115442596-115448998 (+)
FVB/NJ MGP_FVBNJ_G0028445
protein coding gene Chr4:113961106-113967509 (+)
LP/J MGP_LPJ_G0028579
protein coding gene Chr4:119645429-119651860 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028472
protein coding gene Chr4:132318316-132324724 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029126
protein coding gene Chr4:118500785-118507226 (+)
PWK/PhJ MGP_PWKPhJ_G0027522
protein coding gene Chr4:112274370-112280838 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027345
protein coding gene Chr4:114799496-114807307 (+)
WSB/EiJ MGP_WSBEiJ_G0027875
protein coding gene Chr4:118396843-118403240 (+)



Homology
more
  • Human Ortholog
    MED8, mediator complex subunit 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MED8, mediator complex subunit 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC32
  • Links
    NCBI Gene ID: 112950
    neXtProt AC: NX_Q96G25
    UniProt: Q96G25

  • Chr Location
    1p34.2; chr1:43383908-43389812 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Med8
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006392 Ensembl Gene Model | MGI Sequence Detail 6446 C57BL/6J ±  kb
transcript ENSMUST00000019229 Ensembl | MGI Sequence Detail 1145 Not Applicable  
polypeptide ENSMUSP00000019229 Ensembl | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010307 mediator of RNA polymerase II transcription subunit 8
  • InterPro Domains
    IPR019364 Mediator complex, subunit Med8, fungi/metazoa
Molecular
Reagents
less
  • All nucleic 77
    cDNA 76
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1930919
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:215933 Tsai KL, et al., Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. Cell. 2014 Jun 5;157(6):1430-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory