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Zwilch Gene Detail
Summary
  • Symbol
    Zwilch
  • Name
    zwilch kinetochore protein
  • Synonyms
    2310031L18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915264
    NCBI Gene: 68014
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64137144-64172931 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 34.52 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915264
protein coding gene Chr9:64137144-64173104 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034935
protein coding gene Chr9:63772891-63818874 (-)
A/J MGP_AJ_G0034915
protein coding gene Chr9:61653449-61690419 (-)
AKR/J MGP_AKRJ_G0034845
protein coding gene Chr9:63080776-63118767 (-)
BALB/cJ MGP_BALBcJ_G0034908
protein coding gene Chr9:61377692-61413498 (-)
C3H/HeJ MGP_C3HHeJ_G0034618
protein coding gene Chr9:63609869-63651449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035427
protein coding gene Chr9:65508373-65551509 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032338
protein coding gene Chr9:61308083-61343483 (-)
CAST/EiJ MGP_CASTEiJ_G0033939
protein coding gene Chr9:63772121-63811111 (-)
CBA/J MGP_CBAJ_G0034589
protein coding gene Chr9:67773037-67814875 (-)
DBA/2J MGP_DBA2J_G0034748
protein coding gene Chr9:61436100-61471687 (-)
FVB/NJ MGP_FVBNJ_G0034690
protein coding gene Chr9:60738322-60774125 (-)
LP/J MGP_LPJ_G0034831
protein coding gene Chr9:64069908-64108364 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034733
protein coding gene Chr9:69069167-69114544 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035449
protein coding gene Chr9:63194080-63231016 (-)
PWK/PhJ MGP_PWKPhJ_G0033643
protein coding gene Chr9:61588867-61626655 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033477
protein coding gene Chr9:63457146-63499201 (-)
WSB/EiJ MGP_WSBEiJ_G0034052
protein coding gene Chr9:63091646-63129555 (-)



Homology
more
  • Human Ortholog
    ZWILCH, zwilch kinetochore protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZWILCH, zwilch kinetochore protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hZwilch, KNTC1AP
  • Links
    NCBI Gene ID: 55055
    neXtProt AC: NX_Q9H900
    UniProt: Q9H900

  • Chr Location
    15q22.31; chr15:66505083-66549485 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32381
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZWILCH
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68014 NCBI Gene Model | MGI Sequence Detail 35788 C57BL/6J ±  kb
    transcript NM_026507 RefSeq | MGI Sequence Detail 2784 C57BL/6  
    polypeptide Q8R060 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR018630 RZZ complex, subunit Zwilch
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory