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Bambi Gene Detail
Summary
  • Symbol
    Bambi
  • Name
    BMP and activin membrane-bound inhibitor
  • Synonyms
    2610003H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915260
    NCBI Gene: 68010
  • Gene Overview
    MyGene.info: BAMBI
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 18, 2.30 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAMBI, BMP and activin membrane bound inhibitor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BAMBI, BMP and activin membrane bound inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NMA
  • Links
    NCBI Gene ID: 25805
    neXtProt AC: NX_Q13145
    UniProt: Q13145

  • Chr Location
    10p12.1; chr10:28677495-28682939 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele weigh 9% to 10% less than wild-type female mice. Male mice are unaffected. Mice homozygous for one knock-out allele exhibit increased chemical, thermal, and mechanical nociception and decreased nerve injury-induced allodynia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68010 NCBI Gene Model | MGI Sequence Detail 8448 C57BL/6J ±  kb
    transcript NM_026505 RefSeq | MGI Sequence Detail 5040 C57BL/6  
    polypeptide Q9D0L6 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      26 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 34
      Primer pair 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 19
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:262967 Hernandez H, et al., BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2154-2166

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory