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Bambi Gene Detail
Summary
  • Symbol
    Bambi
  • Name
    BMP and activin membrane-bound inhibitor
  • Synonyms
    2610003H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915260
    NCBI Gene: 68010
  • Gene Overview
    MyGene.info: BAMBI
Location & Maps
more
  • Genetic Map
    Chromosome 18, 2.30 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAMBI, BMP and activin membrane bound inhibitor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BAMBI, BMP and activin membrane bound inhibitor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NMA
  • Links
    NCBI Gene ID: 25805
    neXtProt AC: NX_Q13145

  • Chr Location
    10p12.3-p11.2; chr10:28677495-28682939 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Female mice homozygous for a null allele weigh 9% to 10% less than wild-type female mice. Male mice are unaffected. Mice homozygous for one knock-out allele exhibit increased chemical, thermal, and mechanical nociception and decreased nerve injury-induced allodynia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68010 NCBI Gene Model | MGI Sequence Detail 8448 C57BL/6J ±  kb
transcript NM_026505 RefSeq | MGI Sequence Detail 5040 C57BL/6  
polypeptide Q9D0L6 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004636 BMP and activin membrane-bound inhibitor
  • InterPro Domains
    IPR009345 BMP and activin membrane-bound inhibitor
Molecular
Reagents
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  • All nucleic 38
    cDNA 33
    Primer pair 5

    Microarray probesets 2
References
more
  • Summaries
    All 46
    Developmental Gene Expression 17
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:212416 Thomas PS, et al., AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol. 2014 Jun 15;390(2):191-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory