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Srsf6 Gene Detail
Summary
  • Symbol
    Srsf6
  • Name
    serine and arginine-rich splicing factor 6
  • Synonyms
    1210001E11Rik, Sfrs6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915246
    NCBI Gene: 67996
  • Gene Overview
    MyGene.info: SRSF6
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:162931528-162937121 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 83.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915246
protein coding gene Chr2:162931508-162937121 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026813
protein coding gene Chr2:168209371-168214963 (+)
A/J MGP_AJ_G0026779
protein coding gene Chr2:161465419-161471012 (+)
AKR/J MGP_AKRJ_G0026750
protein coding gene Chr2:166221985-166230541 (+)
BALB/cJ MGP_BALBcJ_G0026788
protein coding gene Chr2:161784663-161790256 (+)
C3H/HeJ MGP_C3HHeJ_G0026530
protein coding gene Chr2:166571570-166578477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027236
protein coding gene Chr2:173159180-173164774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024606
protein coding gene Chr2:154759664-154765028 (+)
CAST/EiJ MGP_CASTEiJ_G0025991
protein coding gene Chr2:166931298-166936893 (+)
CBA/J MGP_CBAJ_G0026507
protein coding gene Chr2:179408259-179418641 (+)
DBA/2J MGP_DBA2J_G0026645
protein coding gene Chr2:160634991-160641200 (+)
FVB/NJ MGP_FVBNJ_G0026611
protein coding gene Chr2:159004375-159009882 (+)
LP/J MGP_LPJ_G0026748
protein coding gene Chr2:168358719-168364311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026633
protein coding gene Chr2:183103777-183109371 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027292
protein coding gene Chr2:166104694-166110288 (+)
PWK/PhJ MGP_PWKPhJ_G0025725
protein coding gene Chr2:160177206-160183018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025528
protein coding gene Chr2:164976791-164984160 (+)
WSB/EiJ MGP_WSBEiJ_G0026061
protein coding gene Chr2:166975376-166980968 (+)



Homology
more
  • Human Ortholog
    SRSF6, serine and arginine rich splicing factor 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SRSF6, serine and arginine rich splicing factor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B52, HEL-S-91, SFRS6, SRP55
  • Links
    NCBI Gene ID: 6431
    neXtProt AC: NX_Q13247
    UniProt: Q13247

  • Chr Location
    20q13.11; chr20:43457864-43463605 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016921 Ensembl Gene Model | MGI Sequence Detail 5594 C57BL/6J ±  kb
    transcript ENSMUST00000130411 Ensembl | MGI Sequence Detail 3527 Not Applicable  
    polypeptide ENSMUSP00000119065 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 17
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2138887, MGI:2147715, MGI:2152843
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:66467 Pazzaglia S, et al., Somatic cell hybrids for high-density mapping of chromosome 2 breakpoints in radiation-induced myeloid leukemia cell lines from inbred mice. Mol Carcinog. 2000 Mar;27(3):219-28
    • Latest
      J:294905 Mason MA, et al., Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models. Sci Rep. 2020 Aug 20;10(1):14057

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory