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Atad1 Gene Detail
Summary
  • Symbol
    Atad1
  • Name
    ATPase family, AAA domain containing 1
  • Synonyms
    4921525H23Rik, Thorase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915229
    NCBI Gene: 67979
Location & Maps
more
  • Sequence Map
    Chr19:32672563-32712298 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      39736 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 27.55 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ATAD1, ATPase family, AAA domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATAD1, ATPase family, AAA domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFDC1, FNP001, THORASE
  • Links
    NCBI Gene ID: 84896
    neXtProt AC: NX_Q8NBU5

  • Chr Location
    10q23.31; chr10:87751851-87841349 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 5960
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ATAD1
  • Gene Tree
    Atad1
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body size, seizure, absent LTD, enhanced LTP, enhanced AMPA-mediated currents, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    74
  • Tissues
    12
  • cDNA Data
    15
  • Literature Summary
    1
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000013662 Ensembl Gene Model | MGI Sequence Detail 39736 C57BL/6J ±  kb
transcript ENSMUST00000070210 Ensembl | MGI Sequence Detail 2813 Not Applicable  
polypeptide ENSMUSP00000069962 Ensembl | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    433 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029293 ATPase family AAA domain-containing protein 1
  • EC
    3.6.1.3
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003960 ATPase, AAA-type, conserved site
    IPR003959 ATPase, AAA-type, core
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 17
    cDNA 17

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147704
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:216605 Prendergast J, et al., Ganglioside regulation of AMPA receptor trafficking. J Neurosci. 2014 Sep 24;34(39):13246-58
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory