Atad1 MGI Mouse Gene Detail - MGI:1915229 - ATPase family, AAA domain containing 1

Symbol

Atad1
Name

ATPase family, AAA domain containing 1
Synonyms

4921525H23Rik, Thorase

Feature Type

protein coding gene
IDs

MGI:1915229
NCBI Gene: 67979
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:32672563-32712298 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 27.55 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

433 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915229	protein coding gene	Chr19:32672558-32739767 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025042	protein coding gene	Chr19:31313860-31359381 (-)
A/J	MGP_AJ_G0025019	protein coding gene	Chr19:29756208-29797179 (-)
AKR/J	MGP_AKRJ_G0024987	protein coding gene	Chr19:30798350-30839607 (-)
BALB/cJ	MGP_BALBcJ_G0025018	protein coding gene	Chr19:29818561-29860562 (-)
C3H/HeJ	MGP_C3HHeJ_G0024774	protein coding gene	Chr19:30794930-30836987 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025459	protein coding gene	Chr19:32196941-32237939 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022878	protein coding gene	Chr19:29664785-29703000 (-)
CAST/EiJ	MGP_CASTEiJ_G0024245	protein coding gene	Chr19:30702073-30745703 (-)
CBA/J	MGP_CBAJ_G0024752	protein coding gene	Chr19:33692718-33739085 (-)
DBA/2J	MGP_DBA2J_G0024884	protein coding gene	Chr19:29681264-29723234 (-)
FVB/NJ	MGP_FVBNJ_G0024846	protein coding gene	Chr19:29511707-29549694 (-)
LP/J	MGP_LPJ_G0024969	protein coding gene	Chr19:31327948-31370797 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024873	protein coding gene	Chr19:33546427-33588601 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025514	protein coding gene	Chr19:30858116-30901009 (-)
PWK/PhJ	MGP_PWKPhJ_G0023993	protein coding gene	Chr19:29379147-29426101 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023797	protein coding gene	Chr19:30151366-30272350 (-)
WSB/EiJ	MGP_WSBEiJ_G0024311	protein coding gene	Chr19:30885519-30929832 (-)

Human Ortholog

ATAD1, ATPase family, AAA domain containing 1

Vertebrate Orthologs

10

Human Ortholog

ATAD1, ATPase family, AAA domain containing 1
Orthology source: HGNC, HomoloGene
Synonyms

AFDC1, FNP001, HKPX4, THORASE
Links

HGNC:25903

NCBI Gene ID: 84896

neXtProt AC: NX_Q8NBU5

UniProt: Q8NBU5
Chr Location

10q23.31; chr10:87751512-87841345 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5960
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ATAD1
Gene Tree

Atad1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Gene trapped

30
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased body size, seizure, absent LTD, enhanced LTP, enhanced AMPA-mediated currents, and premature death.

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All GO Annotations

22
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

74
Tissues

12
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atad1

ZFIN atad1a, atad1b

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Atad1 interacts with 297 markers (Mir7-1, Mir15a, Mir15b, ...) View All

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All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS29752.1

Ensembl

ENSMUSG00000013662 (Evidence)
NCBI Gene

67979

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013662	Ensembl Gene Model \| MGI Sequence Detail	39736	C57BL/6J	± kb
transcript	ENSMUST00000070210	Ensembl \| MGI Sequence Detail	2813	Not Applicable
polypeptide	ENSMUSP00000069962	Ensembl \| MGI Sequence Detail	361	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029293 ATPase family AAA domain-containing protein 1

(term hierarchy)
EC

3.6.1.3
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 18

cDNA 18

Microarray probesets 5

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MGI:2147704

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:256131 Pignatelli M, et al., Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning. Neuron. 2017 Jan 18;93(2):425-440

TSS for Atad1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158895	Chr19:32712830-32712843 (-)	-539 bp
Tssr158894	Chr19:32712746-32712760 (-)	-455 bp
Tssr158893	Chr19:32712350-32712359 (-)	-57 bp
Tssr158892	Chr19:32712337-32712340 (-)	-41 bp
Tssr158891	Chr19:32712287-32712336 (-)	-14 bp
Tssr158888	Chr19:32673854-32673866 (-)	38,438 bp
Tssr158887	Chr19:32673501-32673518 (-)	38,788 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 12/04/2018 MGI 6.13