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Puf60 Gene Detail
Summary
  • Symbol
    Puf60
  • Name
    poly-U binding splicing factor 60
  • Synonyms
    2410104I19Rik, 2810454F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915209
    NCBI Gene: 67959
  • Gene Overview
    MyGene.info: PUF60
Location & Maps
more
  • Sequence Map
    Chr15:76070184-76080946 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10763 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 35.32 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PUF60, poly(U) binding splicing factor 60
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PUF60, poly(U) binding splicing factor 60
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIR, RoBPI, SIAHBP1, VRJS
  • Links
    NCBI Gene ID: 22827
    neXtProt AC: NX_Q9UHX1

  • Chr Location
    8q24.3; chr8:143816344-143829386 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8614
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PUF60
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PUF60 associations

Human Disease Mouse Models
       Verheij Syndrome; VRJS   OMIM: 615583
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotype references
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    3
  • Gene trapped
    14
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    5 involving Puf60
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002524 Ensembl Gene Model | MGI Sequence Detail 10763 C57BL/6J ±  kb
transcript ENSMUST00000100527 Ensembl | MGI Sequence Detail 1912 Not Applicable  
polypeptide ENSMUSP00000098096 Ensembl | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920052
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 27
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233347 Matsushita K, et al., Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget. 2015 Mar 10;6(7):5102-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory