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Setd8
Gene Detail
Symbol

Name
ID
Setd8
SET domain containing (lysine methyltransferase) 8
MGI:1915206
Synonyms
2410195B05Rik, PR-SET7
Feature Type
protein coding gene
Genetic Map
Chromosome 5
63.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:124439930-124462308 bp, + strand
From VEGA annotation of GRCm38

  22379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SETD8
Protein SuperFamily: histone H4-K20 methyltransferase
Gene Tree: Setd8

Human
homologs
SETD8, SET domain containing (lysine methyltransferase) 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 387893
neXtProt AC: NX_Q9NQR1

Human Synonyms: KMT5A, PR-Set7, SET07, SET8

Human Chr (Location): 12q24.31; chr12:123383778-123409358 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(87) : Gene trapped(83) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit embryonic lethality. Mice homozygous for an allele lacking exon 7 die prior to implantation.
 
Interactions
Setd8 interacts with 257 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process cell cycle, cell division, ...
Component chromosome, nucleolus, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (4)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase setd8 ; ZFIN setd8a    NEW 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017165 (Evidence)
Ensembl Gene Model ENSMUSG00000049327 (Evidence)
Entrez Gene 67956 (Evidence)
DFCI TC1599075, TC1574608
DoTS DT.87072703, DT.101193601, DT.99860700
NIA Mouse Gene Index U006185
EC 2.1.1.-, 2.1.1.43
Consensus CDS Project CCDS19675.1
International Mouse Phenotyping Consortium Status Setd8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017165 VEGA Gene Model | MGI Sequence Detail 22379 C57BL/6J ±  kb
transcript OTTMUST00000041559 VEGA | MGI Sequence Detail 1348 Not Applicable 
polypeptide OTTMUSP00000018672 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016858 Histone H4-K20 methyltransferase
InterPro IPR001214 SET domain
Protein Ontology PR:000014723 N-lysine methyltransferase SETD8
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:219210 Nikolaou KC, et al., Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 2015 Feb 12;34(4):430-47
All references(44)
Other
accession IDs
MGI:2138801, MGI:2141208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory