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Setd8
Gene Detail
 Symbol
Name
ID
Setd8
SET domain containing (lysine methyltransferase) 8
MGI:1915206
Synonyms 2410195B05Rik, PR-SET7
Feature Type protein coding gene
Genetic Map
Chromosome 5
63.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:124439930-124462308 bp, + strand
From VEGA annotation of GRCm38

  22379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone H4-K20 methyltransferase
Gene Tree: Setd8

Human
homologs
Human Homolog SETD8, SET domain containing (lysine methyltransferase) 8
NCBI Gene ID 387893
neXtProt AC  NX_Q9NQR1
Human Synonyms  KMT5A, PR-Set7, SET07, SET8
Human Chr (Location)  12q24.31; chr12:123384157-123409353 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(87) : Gene trapped(83) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit embryonic lethality. Mice homozygous for an allele lacking exon 7 die prior to implantation.
 
Interactions
Setd8 interacts with 258 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process cell cycle, cell division, ...
Component chromosome, nucleolus, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (2)   
Theiler Stages: 15, 28
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017165 (Evidence)
Ensembl Gene ModelENSMUSG00000049327 (Evidence)
Entrez Gene67956 (Evidence)
DFCITC1574608, TC1599075
DoTSDT.101193601, DT.87072703, DT.99860700
NIA Mouse Gene IndexU006185
EC2.1.1.-, 2.1.1.43
Consensus CDS ProjectCCDS19675.1
International Mouse Knockout Project StatusSetd8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017165 VEGA Gene Model | MGI Sequence Detail 22379 C57BL/6J ±  kb
transcript OTTMUST00000041559 VEGA | MGI Sequence Detail 1348 Not Applicable 
polypeptide OTTMUSP00000018672 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016858 Histone H4-K20 methyltransferase
InterPro IPR001214 SET domain
Protein Ontology PR:000014723 N-lysine methyltransferase SETD8
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:200977 Devilbiss AW, et al., Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3398-407
All references(45)
Other
accession IDs
MGI:2138801, MGI:2141208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory