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Nifk Gene Detail
Summary
  • Symbol
    Nifk
  • Name
    nucleolar protein interacting with the FHA domain of MKI67
  • Synonyms
    C130020J04Rik, Mki67ip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915199
    NCBI Gene: 67949
  • Gene Overview
    MyGene.info: NIFK
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:118321839-118333822 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915199
protein coding gene Chr1:118321839-118333831 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016390
protein coding gene Chr1:121000548-121012481 (+)
A/J MGP_AJ_G0016373
protein coding gene Chr1:116688825-116700742 (+)
AKR/J MGP_AKRJ_G0016338
protein coding gene Chr1:120130415-120143853 (+)
BALB/cJ MGP_BALBcJ_G0016333
protein coding gene Chr1:116943228-116957766 (+)
C3H/HeJ MGP_C3HHeJ_G0016159
protein coding gene Chr1:120302071-120313995 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016794
protein coding gene Chr1:125622028-125633940 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014507
protein coding gene Chr1:110372442-110384188 (+)
CAST/EiJ MGP_CASTEiJ_G0015740
protein coding gene Chr1:119025015-119037043 (+)
CBA/J MGP_CBAJ_G0016132
protein coding gene Chr1:129989243-130001201 (+)
DBA/2J MGP_DBA2J_G0016238
protein coding gene Chr1:115700473-115712583 (+)
FVB/NJ MGP_FVBNJ_G0016237
protein coding gene Chr1:114431900-114443816 (+)
LP/J MGP_LPJ_G0016309
protein coding gene Chr1:122351832-122364094 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016262
protein coding gene Chr1:135784434-135796376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016830
protein coding gene Chr1:119819335-119831274 (+)
PWK/PhJ MGP_PWKPhJ_G0015526
protein coding gene Chr1:114668787-114680979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015314
protein coding gene Chr1:118707357-118719191 (+)
WSB/EiJ MGP_WSBEiJ_G0015802
protein coding gene Chr1:119717906-119729848 (+)



Homology
more
  • Human Ortholog
    NIFK, nucleolar protein interacting with the FHA domain of MKI67
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NIFK, nucleolar protein interacting with the FHA domain of MKI67
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MKI67IP, Nopp34
  • Links
    NCBI Gene ID: 84365
    neXtProt AC: NX_Q9BYG3
    UniProt: Q9BYG3

  • Chr Location
    2q14.3; chr2:121726945-121736927 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49862
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NIFK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Nifk
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026377 Ensembl Gene Model | MGI Sequence Detail 11984 C57BL/6J ±  kb
transcript ENSMUST00000027626 Ensembl | MGI Sequence Detail 1889 Not Applicable  
polypeptide ENSMUSP00000027626 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029630 MKI67 FHA domain-interacting nucleolar phosphoprotein
  • InterPro Domains
    IPR021043 MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138364
References
more
  • Summaries
    All 29
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory