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Serpini2 Gene Detail
Summary
  • Symbol
    Serpini2
  • Name
    serine (or cysteine) peptidase inhibitor, clade I, member 2
  • Synonyms
    1810006A24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915181
    NCBI Gene: 67931
  • Gene Overview
    MyGene.info: SERPINI2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:75242370-75270078 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 33.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915181
protein coding gene Chr3:75242357-75270078 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027304
protein coding gene Chr3:74725787-74757330 (-)
A/J MGP_AJ_G0027266
protein coding gene Chr3:72416346-72444969 (-)
AKR/J MGP_AKRJ_G0027234
protein coding gene Chr3:74053153-74086935 (-)
BALB/cJ MGP_BALBcJ_G0027277
protein coding gene Chr3:72390056-72417313 (-)
C3H/HeJ MGP_C3HHeJ_G0027021
protein coding gene Chr3:74360739-74389245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027723
protein coding gene Chr3:77679057-77709131 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025076
protein coding gene Chr3:68266966-68292587 (-)
CAST/EiJ MGP_CASTEiJ_G0026468
protein coding gene Chr3:74307191-74342051 (-)
CBA/J MGP_CBAJ_G0026996
protein coding gene Chr3:80134226-80170310 (-)
DBA/2J MGP_DBA2J_G0027132
protein coding gene Chr3:71958231-71988896 (-)
FVB/NJ MGP_FVBNJ_G0027100
protein coding gene Chr3:70365227-70394790 (-)
LP/J MGP_LPJ_G0027240
protein coding gene Chr3:75737412-75780633 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027119
protein coding gene Chr3:85964843-85992723 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027781
protein coding gene Chr3:73871132-73904782 (-)
PWK/PhJ MGP_PWKPhJ_G0026202
protein coding gene Chr3:71692272-71720052 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026018
protein coding gene Chr3:72956246-72984520 (-)
WSB/EiJ MGP_WSBEiJ_G0026546
protein coding gene Chr3:74128046-74161666 (-)



Homology
more
  • Human Ortholog
    SERPINI2, serpin family I member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SERPINI2, serpin family I member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEPI, PANCPIN, PI14, TSA2004
  • Links
    NCBI Gene ID: 5276
    neXtProt AC: NX_O75830
    UniProt: O75830

  • Chr Location
    3q26.1; chr3:167441789-167474132 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Serpini2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    2 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgene insertion/deletion encompassing this gene display pancreatic insufficiency characterized by progressive apoptosis of pancreatic acinar cells, postnatal growth retardation, immunological anomalies, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034139 Ensembl Gene Model | MGI Sequence Detail 27709 C57BL/6J ±  kb
transcript ENSMUST00000039047 Ensembl | MGI Sequence Detail 1411 Not Applicable  
polypeptide ENSMUSP00000046943 Ensembl | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Diseases 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory