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Serpini2
Gene Detail
 Symbol
Name
ID
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
MGI:1915181
Synonyms 1810006A24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
33.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:75242370-75270078 bp, - strand
From VEGA annotation of GRCm38

  27709 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: serpin
Gene Tree: Serpini2

Human
homologs
Human Homolog SERPINI2, serpin peptidase inhibitor, clade I (pancpin), member 2
NCBI Gene ID 5276
neXtProt AC  NX_O75830
Human Synonyms  MEPI, PANCPIN, PI14, TSA2004
Human Chr (Location)  3q26.1; chr3:167441789-167474132 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transgene insertion/deletion encompassing this gene display pancreatic insufficiency characterized by progressive apoptosis of pancreatic acinar cells, postnatal growth retardation, immunological anomalies, and premature death.
 
Human Diseases Modeled Using Mouse Serpini2 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Serpini2 interacts with 41 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component extracellular region, extracellular space
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026707 (Evidence)
Ensembl Gene ModelENSMUSG00000034139 (Evidence)
Entrez Gene67931 (Evidence)
UniGene259446
DFCITC1581712
DoTSDT.50316769
NIA Mouse Gene IndexU024159
Consensus CDS ProjectCCDS17413.1
International Mouse Knockout Project StatusSerpini2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026707 VEGA Gene Model | MGI Sequence Detail 27709 C57BL/6J ±  kb
transcript OTTMUST00000066080 VEGA | MGI Sequence Detail 1411 Not Applicable 
polypeptide OTTMUSP00000033045 VEGA | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014710 serpin I2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory