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Epsti1 Gene Detail
Summary
  • Symbol
    Epsti1
  • Name
    epithelial stromal interaction 1 (breast)
  • Synonyms
    2310046K10Rik, 5033415K03Rik, BRESI1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915168
    NCBI Gene: 108670
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:77904239-78002656 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.08 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    429 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915168
protein coding gene Chr14:77904239-78002657 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021587
protein coding gene Chr14:72929646-73033084 (+)
A/J MGP_AJ_G0021545
protein coding gene Chr14:71188937-71287038 (+)
AKR/J MGP_AKRJ_G0021522
protein coding gene Chr14:73302103-73404360 (+)
BALB/cJ MGP_BALBcJ_G0021552
protein coding gene Chr14:70992943-71091622 (+)
C3H/HeJ MGP_C3HHeJ_G0021329
protein coding gene Chr14:73016727-73118313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021992
protein coding gene Chr14:76058099-76167760 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019530
protein coding gene Chr14:68768940-68866509 (+)
CAST/EiJ MGP_CASTEiJ_G0020846
protein coding gene Chr14:69795391-69900388 (+)
CBA/J MGP_CBAJ_G0021297
protein coding gene Chr14:78497687-78598799 (+)
DBA/2J MGP_DBA2J_G0021420
protein coding gene Chr14:70575552-70680845 (+)
FVB/NJ MGP_FVBNJ_G0021398
protein coding gene Chr14:69917297-70018586 (+)
LP/J MGP_LPJ_G0021490
protein coding gene Chr14:74048875-74150024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021425
protein coding gene Chr14:77163113-77271248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022015
protein coding gene Chr14:72593010-72694262 (+)
PWK/PhJ MGP_PWKPhJ_G0020589
protein coding gene Chr14:67355488-67455696 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020426
protein coding gene Chr14:68567375-68681170 (+)
WSB/EiJ MGP_WSBEiJ_G0020899
protein coding gene Chr14:72922442-73025290 (+)



Homology
more
  • Human Ortholog
    EPSTI1, epithelial stromal interaction 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPSTI1, epithelial stromal interaction 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRESI1
  • Links
    NCBI Gene ID: 94240
    neXtProt AC: NX_Q96J88
    UniProt: Q96J88

  • Chr Location
    13q14.11; chr13:42886388-42992271 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enhanced M2 macrophage differentiation and inhibited M1 polarization.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 108670 NCBI Gene Model | MGI Sequence Detail 98418 C57BL/6J ±  kb
transcript NM_029495 RefSeq | MGI Sequence Detail 1869 C57BL/6  
polypeptide Q8VDI1 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    cDNA 48

    Microarray probesets 6
Other
Accession IDs
less
MGI:1923238
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:272013 Kim YH, et al., Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1). Biochem Biophys Res Commun. 2018 Feb 5;496(2):778-783

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory