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Coq9 Gene Detail
Summary
  • Symbol
    Coq9
  • Name
    coenzyme Q9
  • Synonyms
    2310005O14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915164
    NCBI Gene: 67914
  • Gene Overview
    MyGene.info: COQ9
Location & Maps
more
  • Sequence Map
    Chr8:94838321-94854895 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16575 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    COQ9, coenzyme Q9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COQ9, coenzyme Q9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C16orf49, COQ10D5
  • Links
    NCBI Gene ID: 57017
    neXtProt AC: NX_O75208

  • Chr Location
    16q21; chr16:57447425-57461275 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6477
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: COQ9
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Coq9 mouse models; 1 with human COQ9 associations

Human Disease Mouse Models
       Coenzyme Q10 Deficiency, Primary, 5; COQ10D5   OMIM: 614654 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit premature death, encephalomyopathy, hair loss, weight loss, demyelination, cardiac fibrosis and abnromal mitochondrial function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027370 VEGA Gene Model | MGI Sequence Detail 16575 C57BL/6J ±  kb
transcript OTTMUST00000067682 VEGA | MGI Sequence Detail 1789 Not Applicable  
polypeptide OTTMUSP00000034087 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    254 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005757 ubiquinone biosynthesis protein COQ9, mitochondrial
  • InterPro Domains
    IPR012762 Ubiquinone biosynthesis protein COQ9
Molecular
Reagents
less
  • All nucleic 159
    cDNA 159

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142852
References
more
  • Summaries
    All 31
    Diseases 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:229185 Luna-Sanchez M, et al., The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene. EMBO Mol Med. 2015 May;7(5):670-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory