Rgs19
Gene Detail

Symbol Name ID

Rgs19 regulator of G-protein signaling 19 MGI:1915153

Synonyms

2610042F04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

103.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:181688419-181693977 bp, - strand From VEGA annotation of GRCm38   5559 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs19

Human homologs

Human Homolog		RGS19, regulator of G-protein signaling 19
NCBI Gene ID		10287
neXtProt AC		NX_P49795
Human Synonyms		GAIP, RGSGAIP
Human Chr (Location)		20q13.33; chr20:62704534-62711324 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(1) Gene trapped(5)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	negative regulation of signal transduction, termination of G-protein coupled receptor signaling pathway
Component	brush border, clathrin-coated vesicle, ...
Function	G-protein alpha-subunit binding, GTPase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (7)    Images (14)
Theiler Stages: 20, 21, 22, 23

Assay Type	Results
RNA in situ	12

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) cDNA(59) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016814 (Evidence)
Ensembl Gene Model	ENSMUSG00000002458 (Evidence)
Entrez Gene	56470 (Evidence)
UniGene	274366
DFCI	TC1575828, TC1588735, TC1613027, TC1681513
DoTS	DT.101377360, DT.110708228, DT.110708236, DT.492580, DT.91343795, DT.99857363, DT.99857365
NIA Mouse Gene Index	U023795
Consensus CDS Project	CCDS17220.1
International Mouse Knockout Project Status	Rgs19

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016814	VEGA Gene Model | MGI Sequence Detail	5559	C57BL/6J
transcript	OTTMUST00000040846	VEGA | MGI Sequence Detail	1427	Not Applicable
polypeptide	OTTMUSP00000018271	VEGA | MGI Sequence Detail	243	Not Applicable

All sequences(82) RefSeq(2) UniProt(9)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013953	regulator of G-protein signaling 19

References

(Earliest) J:64809 De Vries L, et al., GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12340-5
(Latest) J:188786 Sohn WJ, et al., Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE. Mech Dev. 2012 Sep;129(9-12):244-54
All references(42)

Other accession IDs

MGI:2138902, MGI:2139380