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Rnmt Gene Detail
Summary
  • Symbol
    Rnmt
  • Name
    RNA (guanine-7-) methyltransferase
  • Synonyms
    2610002P10Rik, mKIAA0398
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915147
    NCBI Gene: 67897
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:68433426-68457923 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 41.22 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    819 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915147
 protein coding gene Chr18:68433406-68457923 (+)
129S1/SvImJ ENSMUSG00200022803
 protein coding gene Chr18:65628250-65652750 (+)
A/J ENSMUSG00195032362
 protein coding gene Chr18:65685733-65710235 (+)
AKR/J ENSMUSG00220022738
 protein coding gene Chr18:65643301-65667769 (+)
BALB/cJ ENSMUSG00180011998
 protein coding gene Chr18:66252817-66277324 (+)
C3H/HeJ ENSMUSG00175010268
 protein coding gene Chr18:65845766-65870267 (+)
C57BL/6NJ ENSMUSG00215011021
 protein coding gene Chr18:65193403-65217900 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022378
 protein coding gene Chr18:65020383-65044627 (+)
CAST/EiJ ENSTCUG00005014832
 protein coding gene Chr18:64845606-64871022 (+)
CBA/J ENSMUSG00210030846
 protein coding gene Chr18:65798499-65823000 (+)
DBA/2J ENSMUSG00185028050
 protein coding gene Chr18:65709907-65734408 (+)
FVB/NJ ENSMUSG00205012109
 protein coding gene Chr18:65179019-65203527 (+)
JF1/MsJ ENSUMUG00000020382
 protein coding gene Chr18:65634837-65660365 (+)
LP/J ENSMUSG00230038405
 protein coding gene Chr18:67760659-67785159 (+)
NOD/ShiLtJ ENSMUSG00190007920
 protein coding gene Chr18:65431163-65455664 (+)
NZO/HlLtJ ENSMUSG00225030052
 protein coding gene Chr18:67656620-67681127 (+)
PWK/PhJ ENSLUMG00010022733
 protein coding gene Chr18:66035659-66061342 (+)
SPRET/EiJ ENSMSPG00010035519
 protein coding gene Chr18:66202301-66227639 (+)
WSB/EiJ ENSIUOG00005005593
 protein coding gene Chr18:65254285-65278849 (+)



Homology
more
  • Human Ortholog
    RNMT, RNA guanine-7 methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNMT, RNA guanine-7 methyltransferase
  • Synonyms
    cm1p, CMT1, CMT1c, hCMT1, hMet, N7-MTase, RG7MT1
  • Links
    NCBI Gene ID: 8731
    UniProt: O43148

  • Chr Location
    18p11.21; chr18:13726660-13764556 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    51
  • cDNA Data
    134
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009535 Ensembl Gene Model | MGI Sequence Detail 24498 C57BL/6J ±  kb
transcript ENSMUST00000009679 Ensembl | MGI Sequence Detail 5008 Not Applicable  
polypeptide ENSMUSP00000009679 Ensembl | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014144 mRNA cap guanine-N(7) methyltransferase
    (term hierarchy)
  • EC
    2.1.1.56
  • InterPro Domains
    IPR039753 mRNA cap guanine-N7 methyltransferase
    IPR016899 mRNA cap guanine-N7 methyltransferase, eukaryotes
    IPR004971 mRNA (guanine-N(7))-methyltransferase domain
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
  • GlyGen
    Q9D0L8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 134
    cDNA 134

    Microarray probesets 9
Other
Accession IDs
less
MGI:2147272
References
more
  • Summaries
    All 58
    Developmental Gene Expression 4
    Gene Ontology 14
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:388793 Knop K, et al., RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression. Discov Immunol. 2024;3(1):kyad021
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory