Ccdc80 MGI Mouse Gene Detail - MGI:1915146 - coiled-coil domain containing 80

Ccdc80 Gene Detail

Symbol

Ccdc80
Name

coiled-coil domain containing 80
Synonyms

2610001E17Rik, DRO1, Ssg1, Urb

Feature Type

protein coding gene
IDs

MGI:1915146
NCBI Gene: 67896
Gene Overview

MyGene.info: CCDC80

Sequence Map

Chr16:45093402-45127665 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

34264 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.39 cM, cytoband B5
Mapping Data

4 experiments

Human Ortholog

CCDC80, coiled-coil domain containing 80

Vertebrate Orthologs

9

Human Ortholog

CCDC80, coiled-coil domain containing 80
Orthology source: HomoloGene, HGNC
Synonyms

DRO1, okuribin, SSG1, URB
Links

HGNC:30649

NCBI Gene ID: 151887

neXtProt AC: NX_Q76M96

UniProt: Q76M96
Chr Location

3q13.2; chr3:112604386-112641143 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12206
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: CCDC80
Gene Tree

Ccdc80

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 4 alleles in 4 genetic backgrounds
6 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a null allele exhibit increased adiposity, hyperglycemia, glucose intolerance, impaired insulin secretion, and altered energy intake and expenditure when fed a high-fat diet. Mice homozygous for a different null allele develop thyroid adenomas and ovarian carcinomas.

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All GO Annotations

10
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

9
Tissues

8
cDNA Data

104
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc80

ZFIN ccdc80

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Ccdc80 interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

44
RefSeq

10
UniProt

1
CCDS

CCDS28192.1
UniGene

181074

			Length	Strain/Species	Flank
genomic	OTTMUSG00000025346	VEGA Gene Model \| MGI Sequence Detail	34264	C57BL/6J	± kb
transcript	OTTMUST00000062389	VEGA \| MGI Sequence Detail	3671	Not Applicable
polypeptide	OTTMUSP00000030743	VEGA \| MGI Sequence Detail	949	Not Applicable

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SNPs within 2kb

303 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000005104 coiled-coil domain-containing protein 80

(term hierarchy)
InterPro Domains

IPR025232 Domain of unknown function DUF4174

IPR015943 WD40/YVTN repeat-like-containing domain

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All nucleic 107

cDNA 104

Primer pair 2

Other 1

Microarray probesets 4

Summaries

All 37

Developmental Gene Expression 4

Diseases 1

Gene Ontology 3

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:217742 Leone V, et al., The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias. Cancer Lett. 2015 Feb 28;357(2):535-41

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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