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Ccdc80 Gene Detail
Summary
  • Symbol
    Ccdc80
  • Name
    coiled-coil domain containing 80
  • Synonyms
    2610001E17Rik, DRO1, Ssg1, Urb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915146
    NCBI Gene: 67896
  • Gene Overview
    MyGene.info: CCDC80
Location & Maps
more
  • Sequence Map
    Chr16:45093402-45127665 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34264 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.39 cM, cytoband B5
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CCDC80, coiled-coil domain containing 80
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCDC80, coiled-coil domain containing 80
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRO1, okuribin, SSG1, URB
  • Links
    NCBI Gene ID: 151887
    neXtProt AC: NX_Q76M96

  • Chr Location
    3q13.2; chr3:112604386-112641143 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null allele exhibit increased adiposity, hyperglycemia, glucose intolerance, impaired insulin secretion, and altered energy intake and expenditure when fed a high-fat diet. Mice homozygous for a different null allele develop thyroid adenomas and ovarian carcinomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025346 VEGA Gene Model | MGI Sequence Detail 34264 C57BL/6J ±  kb
transcript OTTMUST00000062389 VEGA | MGI Sequence Detail 3671 Not Applicable  
polypeptide OTTMUSP00000030743 VEGA | MGI Sequence Detail 949 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    303 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005104 coiled-coil domain-containing protein 80
  • InterPro Domains
    IPR025232 Domain of unknown function DUF4174
    IPR028768 Sushi repeat-containing protein SRPX2
Molecular
Reagents
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  • All nucleic 106
    cDNA 104
    Primer pair 1
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:217742 Leone V, et al., The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias. Cancer Lett. 2015 Feb 28;357(2):535-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory