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Ccdc80
Gene Detail
Symbol

Name
ID
Ccdc80
coiled-coil domain containing 80
MGI:1915146
Synonyms
2610001E17Rik, DRO1, Ssg1, Urb
Feature Type
protein coding gene
Genetic Map
Chromosome 16
29.39 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:45093402-45127665 bp, + strand
From VEGA annotation of GRCm38

  34264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CCDC80
Gene Tree: Ccdc80

Human
homologs
CCDC80, coiled-coil domain containing 80
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 151887
neXtProt AC: NX_Q76M96

Human Synonyms: DRO1, okuribin, SSG1, URB

Human Chr (Location): 3q13.2; chr3:112604386-112641143 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased body fat, increased circulating leptin, glucose and free fatty acid levels, impaired glucose tolerance, increased insulin secretion, and islet hyperplasia when fed a high fat diet.
 
Interactions
Ccdc80 interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (7)    Tissues (7)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 1
cDNA source data(104)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccdc80 ; ZFIN ccdc80    NEW 
Molecular
reagents
All nucleic(106) cDNA(104) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025346 (Evidence)
Ensembl Gene Model ENSMUSG00000022665 (Evidence)
Entrez Gene 67896 (Evidence)
UniGene 181074
DFCI TC1575807, TC1587273
DoTS DT.55100196, DT.99860269
NIA Mouse Gene Index U040810
Consensus CDS Project CCDS28192.1
International Mouse Phenotyping Consortium Status Ccdc80
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025346 VEGA Gene Model | MGI Sequence Detail 34264 C57BL/6J ±  kb
transcript OTTMUST00000062389 VEGA | MGI Sequence Detail 3671 Not Applicable 
polypeptide OTTMUSP00000030743 VEGA | MGI Sequence Detail 949 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025232 Domain of unknown function DUF4174
Protein Ontology PR:000005104 coiled-coil domain-containing protein 80
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189183 Tremblay F, et al., Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice. Endocrinology. 2012 Sep;153(9):4290-303
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory