Ccdc80
Gene Detail

Symbol

Name
ID

Ccdc80
coiled-coil domain containing 80
MGI:1915146

Synonyms

2610001E17Rik, DRO1, Ssg1, Urb

Feature Type

protein coding gene

Genetic Map

Chromosome 16
29.39 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:45093402-45127665 bp, + strand From VEGA annotation of GRCm38   34264 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:12206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ccdc80

Human
homologs

Human Homolog		CCDC80, coiled-coil domain containing 80
NCBI Gene ID		151887
neXtProt AC		NX_Q76M96
Human Synonyms		DRO1, okuribin, SSG1, URB
Human Chr (Location)		3q13.2; chr3:112604386-112641143 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit increased body fat, increased circulating leptin, glucose and free fatty acid levels, impaired glucose tolerance, increased insulin secretion, and islet hyperplasia when fed a high fat diet.

 

Interactions

Ccdc80 interacts with 149 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (9 annotations)

Process	extracellular matrix organization, positive regulation of cell-substrate adhesion
Component	basement membrane, extracellular region, ...
Function	fibronectin binding, glycosaminoglycan binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (7)    Tissues (7)    Images (4)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	6
RNA in situ	1

cDNA source data(104)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(106) cDNA(104) Primer pair(1) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000025346 (Evidence)
Ensembl Gene Model	ENSMUSG00000022665 (Evidence)
Entrez Gene	67896 (Evidence)
UniGene	181074
DFCI	TC1587273, TC1575807
DoTS	DT.55100196, DT.99860269
NIA Mouse Gene Index	U040810
Consensus CDS Project	CCDS28192.1
International Mouse Knockout Project Status	Ccdc80

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025346	VEGA Gene Model | MGI Sequence Detail	34264	C57BL/6J
transcript	OTTMUST00000062389	VEGA | MGI Sequence Detail	3671	Not Applicable
polypeptide	OTTMUSP00000030743	VEGA | MGI Sequence Detail	949	Not Applicable

All sequences(49) RefSeq(10) UniProt(1)

Polymorphisms

SNPs within 2kb(310 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR025232	Domain of unknown function DUF4174
Protein Ontology	PR:000005104	coiled-coil domain-containing protein 80

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189183 Tremblay F, et al., Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice. Endocrinology. 2012 Sep;153(9):4290-303
All references(39)