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Tmem100 Gene Detail
Summary
  • Symbol
    Tmem100
  • Name
    transmembrane protein 100
  • Synonyms
    1810057C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915138
    NCBI Gene: 67888
Location & Maps
more
  • Sequence Map
    Chr11:90030348-90036508 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6161 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 54.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TMEM100, transmembrane protein 100
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM100, transmembrane protein 100
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 55273
    neXtProt AC: NX_Q9NV29

  • Chr Location
    17q22; chr17:55719627-55732121 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 6 alleles in 5 genetic backgrounds
    4 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Targeted
    13
  • Genomic Mutations
    4 involving Tmem100
Mice homozygous for a null mutations display prenatal lethality. Mice homozygous for one null mutation display defects in arterial differentiation and maturation and complete lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001282 VEGA Gene Model | MGI Sequence Detail 6161 C57BL/6J ±  kb
transcript OTTMUST00000002554 VEGA | MGI Sequence Detail 1767 Not Applicable  
polypeptide OTTMUSP00000001262 VEGA | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030673 transmembrane protein 100
  • InterPro Domains
    IPR032536 Transmembrane protein 100
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 3
Other
Accession IDs
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MGI:2144451
References
more
  • Summaries
    All 36
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:219559 Weng HJ, et al., Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015 Feb 18;85(4):833-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory