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Saraf Gene Detail
Summary
  • Symbol
    Saraf
  • Name
    store-operated calcium entry-associated regulatory factor
  • Synonyms
    1810045K07Rik, Tmem66
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915137
    NCBI Gene: 67887
  • Gene Overview
    MyGene.info: SARAF
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34154575-34170821 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.90 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915137
protein coding gene Chr8:34154563-34170847 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033533
protein coding gene Chr8:32661269-32677592 (+)
A/J MGP_AJ_G0033513
protein coding gene Chr8:31377946-31394638 (+)
AKR/J MGP_AKRJ_G0033437
protein coding gene Chr8:32363823-32380841 (+)
BALB/cJ MGP_BALBcJ_G0033509
protein coding gene Chr8:31494326-31510929 (+)
C3H/HeJ MGP_C3HHeJ_G0033221
protein coding gene Chr8:32683908-32700996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034025
protein coding gene Chr8:33887087-33910992 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030974
protein coding gene Chr8:28366125-28381701 (+)
CAST/EiJ MGP_CASTEiJ_G0032548
protein coding gene Chr8:32146564-32174818 (+)
CBA/J MGP_CBAJ_G0033199
protein coding gene Chr8:35207690-35228587 (+)
DBA/2J MGP_DBA2J_G0033352
protein coding gene Chr8:31352114-31368348 (+)
FVB/NJ MGP_FVBNJ_G0033297
protein coding gene Chr8:31007847-31023944 (+)
LP/J MGP_LPJ_G0033442
protein coding gene Chr8:32614643-32630640 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033339
protein coding gene Chr8:34735166-34752170 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034044
protein coding gene Chr8:32441812-32461483 (+)
PWK/PhJ MGP_PWKPhJ_G0032260
protein coding gene Chr8:30878300-30906561 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032091
protein coding gene Chr8:31712549-31738873 (+)
WSB/EiJ MGP_WSBEiJ_G0032664
protein coding gene Chr8:32624308-32640769 (+)



Homology
more
  • Human Ortholog
    SARAF, store-operated calcium entry associated regulatory factor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SARAF, store-operated calcium entry associated regulatory factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FOAP-7, HSPC035, TMEM66, XTP3
  • Links
    NCBI Gene ID: 51669
    neXtProt AC: NX_Q96BY9
    UniProt: Q96BY9

  • Chr Location
    8p12; chr8:30063012-30083458 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031532 Ensembl Gene Model | MGI Sequence Detail 16247 C57BL/6J ±  kb
transcript ENSMUST00000033933 Ensembl | MGI Sequence Detail 1860 Not Applicable  
polypeptide ENSMUSP00000033933 Ensembl | MGI Sequence Detail 363 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR009567 Store-operated calcium entry-associated regulatory factor
Molecular
Reagents
less
  • All nucleic 230
    cDNA 230

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:237455 Lodder EM, et al., Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition. Circ Cardiovasc Genet. 2014 Dec;7(6):790-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory