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Uxs1 Gene Detail
Summary
  • Symbol
    Uxs1
  • Name
    UDP-glucuronate decarboxylase 1
  • Synonyms
    1600025I13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915133
    NCBI Gene: 67883
  • Gene Overview
    MyGene.info: UXS1
Location & Maps
more
  • Sequence Map
    Chr1:43746966-43827800 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80835 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 23.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UXS1, UDP-glucuronate decarboxylase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UXS1, UDP-glucuronate decarboxylase 1
    Orthology source: HomoloGene
  • Synonyms
    SDR6E1, UGD
  • Links
    NCBI Gene ID: 80146
    neXtProt AC: NX_Q8NBZ7

  • Chr Location
    2q12.2; chr2:106093303-106194339 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41609
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: UXS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    3
  • Genomic Mutations
    1 involving Uxs1
  • Incidental Mutations
Mice homozygous for a null allele die prenatally. Heterozygous mice exhibit an increased mean serum IgG2a response to ovalbumin challenge when compared with that of controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030350 VEGA Gene Model | MGI Sequence Detail 80835 C57BL/6J ±  kb
transcript OTTMUST00000075193 VEGA | MGI Sequence Detail 4620 Not Applicable  
polypeptide OTTMUSP00000039355 VEGA | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    532 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017215 UDP-glucuronic acid decarboxylase 1
  • EC
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR021761 UDP-glucuronate decarboxylase N-terminal
Molecular
Reagents
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  • All nucleic 35
    cDNA 35

    Microarray probesets 5
Other
Accession IDs
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MGI:2138257, MGI:2138315, MGI:2138607
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory