Dcxr MGI Mouse Gene Detail - MGI:1915130 - dicarbonyl L-xylulose reductase

Symbol

Dcxr
Name

dicarbonyl L-xylulose reductase
Synonyms

0610038K04Rik, 1810027P18Rik

Feature Type

protein coding gene
IDs

MGI:1915130
NCBI Gene: 67880
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:120616225-120618107 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 84.47 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

121 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915130	protein coding gene	Chr11:120615372-120618110 (-)
129S1/SvImJ	ENSMUSG00200050318	protein coding gene	Chr11:117979635-117981519 (-)
A/J	ENSMUSG00195027010	protein coding gene	Chr11:117654711-117656598 (-)
AKR/J	ENSMUSG00220023548	protein coding gene	Chr11:117805099-117806983 (-)
BALB/cJ	ENSMUSG00180049651	protein coding gene	Chr11:117947375-117949257 (-)
C3H/HeJ	ENSMUSG00175042116	protein coding gene	Chr11:117905170-117907054 (-)
C57BL/6NJ	ENSMUSG00215043902	protein coding gene	Chr11:117475219-117477104 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017542	protein coding gene	Chr11:116626319-116628188 (-)
CAST/EiJ	ENSTCUG00005034849	protein coding gene	Chr11:117335378-117337243 (-)
CBA/J	ENSMUSG00210048854	protein coding gene	Chr11:117619213-117621094 (-)
DBA/2J	ENSMUSG00185024544	protein coding gene	Chr11:117932361-117934244 (-)
FVB/NJ	ENSMUSG00205043931	protein coding gene	Chr11:117780081-117781965 (-)
JF1/MsJ	ENSUMUG00000036509	protein coding gene	Chr11:118226755-118228630 (-)
LP/J	ENSMUSG00230050166	protein coding gene	Chr11:118998871-119000753 (-)
NOD/ShiLtJ	ENSMUSG00190047938	protein coding gene	Chr11:118003584-118005467 (-)
NZO/HlLtJ	ENSMUSG00225052191	protein coding gene	Chr11:121147223-121149105 (-)
PWK/PhJ	ENSLUMG00010019605	protein coding gene	Chr11:117744207-117746083 (-)
SPRET/EiJ	ENSMSPG00010032292	protein coding gene	Chr11:118315323-118317186 (-)
WSB/EiJ	ENSIUOG00005045783	protein coding gene	Chr11:117737949-117739832 (-)

Human Ortholog

DCXR, dicarbonyl and L-xylulose reductase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCXR, dicarbonyl and L-xylulose reductase
Synonyms

DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
Links

HGNC:18985

NCBI Gene ID: 51181

UniProt: Q7Z4W1
Chr Location

17q25.3; chr17:82035136-82037776 (-) GRCh38

MGI Vertebrate Homology

Dcxr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCXR
Gene Tree

Dcxr

Diseases

1 with human DCXR associations

				Human Disease	Mouse Models
				pentosuria IDs pentosuria DOID:0111258 ICD10CM:E74.89 MESH:C536652 OMIM:260800 ORDO:2843 UMLS_CUI:C0268162

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

41
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

118
cDNA Data

73
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcxr

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All Sequences

48
RefSeq

4
UniProt

2
CCDS

CCDS25755.1, CCDS83949.1

Ensembl

ENSMUSG00000039450 (Evidence)
NCBI Gene

67880

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039450	Ensembl Gene Model \| MGI Sequence Detail	1883	C57BL/6J	± kb
transcript	ENSMUST00000026144	Ensembl \| MGI Sequence Detail	892	Not Applicable
polypeptide	ENSMUSP00000026144	Ensembl \| MGI Sequence Detail	244	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006336 L-xylulose reductase

(term hierarchy)
EC

1.1.1.10
InterPro Domains

IPR051737 L-xylulose reductase/Carbonyl reductase

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

Q91X52 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 73

cDNA 73

Microarray probesets 4

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MGI:1917589

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 8
Earliest

J:323240 Tulsiani DR, et al., Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Diabetes. 1979 Sep;28(9):793-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dcxr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112373	Chr11:120618140-120618147 (-)	-37 bp
Tssr112372	Chr11:120618119-120618132 (-)	-19 bp
Tssr112371	Chr11:120618052-120618118 (-)	22 bp
Tssr112370	Chr11:120617485-120617493 (-)	618 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24