Rgs10
Gene Detail

Symbol Name ID

Rgs10 regulator of G-protein signalling 10 MGI:1915115

Synonyms

2310010N19Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

70.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:128373621-128418758 bp, - strand From VEGA annotation of GRCm38   45138 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rgs10 ± 2 cM)

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs10

Human ortholog

RGS10 regulator of G-protein signaling 10 NCBI Gene ID 6001
Human Chr10:121259339-121302222 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(9) : Targeted(1) Gene trapped(8)
 

A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	negative regulation of signal transduction, termination of G-protein coupled receptor signaling pathway
Component	axon terminus, cytoplasm, ...
Function	GTPase activator activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (14)    Tissues (7)   
Theiler Stages: 1, 2, 3, 5, 28

Assay Type	Results
RT-PCR	14

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022902 (Evidence)
Ensembl Gene Model	ENSMUSG00000030844 (Evidence)
Entrez Gene	67865 (Evidence)
UniGene	18635
DFCI	TC1578141
DoTS	DT.531098, DT.94256530
NIA Mouse Gene Index	U029321
Consensus CDS Project	CCDS21896.1
International Mouse Knockout Project Status	Rgs10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022902	VEGA Gene Model | MGI Sequence Detail	45138	C57BL/6J
transcript	OTTMUST00000055088	VEGA | MGI Sequence Detail	880	Not Applicable
polypeptide	OTTMUSP00000026329	VEGA | MGI Sequence Detail	181	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(178 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013945	regulator of G-protein signaling 10

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)