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Rgs10 Gene Detail
Summary
  • Symbol
    Rgs10
  • Name
    regulator of G-protein signalling 10
  • Synonyms
    2310010N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915115
    NCBI Gene: 67865
  • Gene Overview
    MyGene.info: RGS10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:128373621-128418758 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45138 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 70.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RGS10, regulator of G protein signaling 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RGS10, regulator of G protein signaling 10
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6001
    neXtProt AC: NX_O43665
    UniProt: O43665

  • Chr Location
    10q26.11; chr10:119499813-119542752 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022902 VEGA Gene Model | MGI Sequence Detail 45138 C57BL/6J ±  kb
    transcript OTTMUST00000055088 VEGA | MGI Sequence Detail 880 Not Applicable  
    polypeptide OTTMUSP00000026329 VEGA | MGI Sequence Detail 181 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      270 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:250672 Hensch NR, et al., RGS10 Negatively Regulates Platelet Activation and Thrombogenesis. PLoS One. 2016;11(11):e0165984

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory