Slc25a11 MGI Mouse Gene Detail - MGI:1915113 - solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11

Symbol

Slc25a11
Name

solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
Synonyms

2310022P18Rik, 2oxoc

Feature Type

protein coding gene
IDs

MGI:1915113
NCBI Gene: 67863
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:70535022-70538305 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM
Mapping Data

2 experiments

SNPs within 2kb

44 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915113	protein coding gene	Chr11:70534845-70538356 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018607	protein coding gene	Chr11:71187388-71190671 (-)
A/J	MGP_AJ_G0018575	protein coding gene	Chr11:68498782-68502065 (-)
AKR/J	MGP_AKRJ_G0018544	protein coding gene	Chr11:70556054-70559339 (-)
BALB/cJ	MGP_BALBcJ_G0018547	protein coding gene	Chr11:68807940-68811223 (-)
C3H/HeJ	MGP_C3HHeJ_G0018360	protein coding gene	Chr11:70574707-70577989 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018998	protein coding gene	Chr11:73344512-73347794 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016643	protein coding gene	Chr11:65406231-65409573 (-)
CAST/EiJ	MGP_CASTEiJ_G0017915	protein coding gene	Chr11:70832044-70835324 (-)
CBA/J	MGP_CBAJ_G0018332	protein coding gene	Chr11:76648180-76651463 (-)
DBA/2J	MGP_DBA2J_G0018442	protein coding gene	Chr11:68072071-68075354 (-)
FVB/NJ	MGP_FVBNJ_G0018432	protein coding gene	Chr11:67712762-67716043 (-)
LP/J	MGP_LPJ_G0018512	protein coding gene	Chr11:71768029-71771312 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018455	protein coding gene	Chr11:77203282-77206565 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019040	protein coding gene	Chr11:70813255-70816538 (-)
PWK/PhJ	MGP_PWKPhJ_G0017689	protein coding gene	Chr11:68719183-68722497 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017479	protein coding gene	Chr11:70627487-70630765 (-)
WSB/EiJ	MGP_WSBEiJ_G0017969	protein coding gene	Chr11:70472679-70475962 (-)

Human Ortholog

SLC25A11, solute carrier family 25 member 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A11, solute carrier family 25 member 11
Synonyms

OGC, PGL6, PPGL6, SLC20A4
Links

HGNC:10981

NCBI Gene ID: 8402

UniProt: Q02978
Chr Location

17p13.2; chr17:4937130-4940053 (-) GRCh38

MGI Vertebrate Homology

Slc25a11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC25A11
Gene Tree

Slc25a11

Diseases

1 with human SLC25A11 associations

				Human Disease	Mouse Models
				paraganglioma IDs paraganglioma DOID:0050773 MESH:D010235 NCI:C3308 OMIM:115310 OMIM:168000 OMIM:601650 OMIM:605373 OMIM:614165 OMIM:PS168000 UMLS_CUI:C0030421

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Genomic Mutations

2 involving Slc25a11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Homozygous knockout is embryonic lethal. Heterozygous KO reduces the tumor incidence of Kras activation mutation-induced lung tumors.

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All GO Annotations

26
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a11

ZFIN slc25a11

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All Sequences

67
RefSeq

4
UniProt

5
CCDS

CCDS24958.1

Ensembl

ENSMUSG00000014606 (Evidence)
NCBI Gene

67863

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014606	Ensembl Gene Model \| MGI Sequence Detail	3284	C57BL/6J	± kb
transcript	ENSMUST00000014750	Ensembl \| MGI Sequence Detail	1711	Not Applicable
polypeptide	ENSMUSP00000014750	Ensembl \| MGI Sequence Detail	314	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015006 mitochondrial 2-oxoglutarate/malate carrier protein

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR050391 Mitochondrial Metabolite Transporter

IPR018108 Mitochondrial substrate/solute carrier
GlyGen

Q9CR62 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

Genomic 2

cDNA 10

Primer pair 1

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 14

Phenotypes 16
Earliest

J:327631 Sluse FE, et al., Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition. Eur J Biochem. 1973 Jan 15;32(2):283-91
Latest

J:327478 Yuan Y, et al., alpha-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling. Sci Adv. 2022 May 6;8(18):eabn2879

TSS for Slc25a11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108991	Chr11:70539834-70539841 (-)	-1,533 bp
Tssr108990	Chr11:70537878-70537889 (-)	421 bp
Tssr108989	Chr11:70537798-70537873 (-)	469 bp
Tssr108988	Chr11:70537715-70537793 (-)	551 bp
Tssr108987	Chr11:70537690-70537714 (-)	603 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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