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Slc25a11 Gene Detail
Summary
  • Symbol
    Slc25a11
  • Name
    solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
  • Synonyms
    2310022P18Rik, 2oxoc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915113
    NCBI Gene: 67863
  • Gene Overview
    MyGene.info: SLC25A11
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70535022-70538305 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915113
 protein coding gene Chr11:70534845-70538356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018607
 protein coding gene Chr11:71187388-71190671 (-)
A/J MGP_AJ_G0018575
 protein coding gene Chr11:68498782-68502065 (-)
AKR/J MGP_AKRJ_G0018544
 protein coding gene Chr11:70556054-70559339 (-)
BALB/cJ MGP_BALBcJ_G0018547
 protein coding gene Chr11:68807940-68811223 (-)
C3H/HeJ MGP_C3HHeJ_G0018360
 protein coding gene Chr11:70574707-70577989 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018998
 protein coding gene Chr11:73344512-73347794 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016643
 protein coding gene Chr11:65406231-65409573 (-)
CAST/EiJ MGP_CASTEiJ_G0017915
 protein coding gene Chr11:70832044-70835324 (-)
CBA/J MGP_CBAJ_G0018332
 protein coding gene Chr11:76648180-76651463 (-)
DBA/2J MGP_DBA2J_G0018442
 protein coding gene Chr11:68072071-68075354 (-)
FVB/NJ MGP_FVBNJ_G0018432
 protein coding gene Chr11:67712762-67716043 (-)
LP/J MGP_LPJ_G0018512
 protein coding gene Chr11:71768029-71771312 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018455
 protein coding gene Chr11:77203282-77206565 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019040
 protein coding gene Chr11:70813255-70816538 (-)
PWK/PhJ MGP_PWKPhJ_G0017689
 protein coding gene Chr11:68719183-68722497 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017479
 protein coding gene Chr11:70627487-70630765 (-)
WSB/EiJ MGP_WSBEiJ_G0017969
 protein coding gene Chr11:70472679-70475962 (-)



Homology
more
  • Human Ortholog
    SLC25A11, solute carrier family 25 member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A11, solute carrier family 25 member 11
  • Synonyms
    OGC, PGL6, SLC20A4
  • Links
    NCBI Gene ID: 8402
    neXtProt AC: NX_Q02978
    UniProt: Q02978

  • Chr Location
    17p13.2; chr17:4937130-4940167 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    13 phenotype references
Homozygous knockout is embryonic lethal. Heterozygous KO reduces the tumor incidence of Kras activation mutation-induced lung tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    1
  • cDNA Data
    10
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014606 Ensembl Gene Model | MGI Sequence Detail 3284 C57BL/6J ±  kb
transcript ENSMUST00000014750 Ensembl | MGI Sequence Detail 1711 Not Applicable  
polypeptide ENSMUSP00000014750 Ensembl | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015006 mitochondrial 2-oxoglutarate/malate carrier protein
    (term hierarchy)
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain superfamily
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:294965 Lee JS, et al., Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation. EBioMedicine. 2019 Feb;40:184-197
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/05/2021
MGI 6.17 		The Jackson Laboratory