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Akr1b10 Gene Detail
Summary
  • Symbol
    Akr1b10
  • Name
    aldo-keto reductase family 1, member B10 (aldose reductase)
  • Synonyms
    2310005E10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915111
    NCBI Gene: 67861
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34384218-34396950 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 14.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915111
protein coding gene Chr6:34384207-34396956 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030558
protein coding gene Chr6:32463947-32477476 (+)
A/J MGP_AJ_G0030531
protein coding gene Chr6:31080603-31093186 (+)
AKR/J MGP_AKRJ_G0030458
protein coding gene Chr6:32126218-32146625 (+)
BALB/cJ MGP_BALBcJ_G0030541
protein coding gene Chr6:31260787-31273645 (+)
C3H/HeJ MGP_C3HHeJ_G0030254
protein coding gene Chr6:32083615-32096708 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030995
protein coding gene Chr6:33285646-33298363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028206
protein coding gene Chr6:29167317-29180012 (+)
CAST/EiJ MGP_CASTEiJ_G0029656
protein coding gene Chr6:31905046-31919047 (+)
CBA/J MGP_CBAJ_G0030232
protein coding gene Chr6:34557636-34570247 (+)
DBA/2J MGP_DBA2J_G0030376
protein coding gene Chr6:30956406-30969252 (+)
FVB/NJ MGP_FVBNJ_G0030330
protein coding gene Chr6:30748633-30761572 (+)
LP/J MGP_LPJ_G0030463
protein coding gene Chr6:32596099-32609597 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030366
protein coding gene Chr6:36905724-36919459 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031025
protein coding gene Chr6:32005741-32020469 (+)
PWK/PhJ MGP_PWKPhJ_G0029370
protein coding gene Chr6:30566319-30580163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029206
protein coding gene Chr6:31670789-31676565 (+)
WSB/EiJ MGP_WSBEiJ_G0029732
protein coding gene Chr6:31920160-31937826 (+)



Homology
more
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Vertebrate Orthologs
    4
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
    Orthology source: HGNC
  • Synonyms
    AKR1B11, AKR1B12, ALDRLn, ARL1, ARL-1, HIS, HSI
  • Links
    NCBI Gene ID: 57016
    neXtProt AC: NX_O60218
    UniProt: O60218

  • Chr Location
    7q33; chr7:134527592-134541414 (+)  GRCh38.p7

  • Human Ortholog
    AKR1B15, aldo-keto reductase family 1 member B15
    Orthology source: HGNC
  • Synonyms
    AKR1B10L, AKR1B10L, AK1R1B7, AKR1R1B7
  • Links
    NCBI Gene ID: 441282
    neXtProt AC: NX_C9JRZ8
    UniProt: C9JRZ8

  • Chr Location
    7q33; chr7:134549097-134579841 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061758 Ensembl Gene Model | MGI Sequence Detail 12733 C57BL/6J ±  kb
transcript ENSMUST00000038383 Ensembl | MGI Sequence Detail 1371 Not Applicable  
polypeptide ENSMUSP00000039114 Ensembl | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR020471 Aldo/keto reductase
    IPR018170 Aldo/keto reductase, conserved site
    IPR023210 NADP-dependent oxidoreductase domain
    IPR036812 NADP-dependent oxidoreductase domain superfamily
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:200524 Li H, et al., Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10). Carcinogenesis. 2013 Sep;34(9):2090-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory