S100a16 MGI Mouse Gene Detail - MGI:1915110 - S100 calcium binding protein A16

Symbol

S100a16
Name

S100 calcium binding protein A16
Synonyms

2300002L21Rik

Feature Type

protein coding gene
IDs

MGI:1915110
NCBI Gene: 67860
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:90444561-90450458 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.25 cM, cytoband F1-F2
Mapping Data

4 experiments

SNPs within 2kb

30 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915110	protein coding gene	Chr3:90444561-90450458 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027471	protein coding gene	Chr3:90866315-90872213 (+)
A/J	MGP_AJ_G0027435	protein coding gene	Chr3:87832474-87838371 (+)
AKR/J	MGP_AKRJ_G0027400	protein coding gene	Chr3:89992051-89997946 (+)
BALB/cJ	MGP_BALBcJ_G0027444	protein coding gene	Chr3:87786404-87792315 (+)
C3H/HeJ	MGP_C3HHeJ_G0027186	protein coding gene	Chr3:90158158-90164053 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027890	protein coding gene	Chr3:94268088-94274835 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025243	protein coding gene	Chr3:83327139-83332998 (+)
CAST/EiJ	MGP_CASTEiJ_G0026632	protein coding gene	Chr3:90548389-90554281 (+)
CBA/J	MGP_CBAJ_G0027161	protein coding gene	Chr3:97481144-97487039 (+)
DBA/2J	MGP_DBA2J_G0027298	protein coding gene	Chr3:87197723-87203633 (+)
FVB/NJ	MGP_FVBNJ_G0027266	protein coding gene	Chr3:85530405-85536302 (+)
LP/J	MGP_LPJ_G0027407	protein coding gene	Chr3:91923326-91929223 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027287	protein coding gene	Chr3:103715246-103721155 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027949	protein coding gene	Chr3:89742712-89748612 (+)
PWK/PhJ	MGP_PWKPhJ_G0026366	protein coding gene	Chr3:87094284-87100360 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026186	protein coding gene	Chr3:88918929-88924850 (+)
WSB/EiJ	MGP_WSBEiJ_G0026714	protein coding gene	Chr3:90150052-90155970 (+)

Human Ortholog

S100A16, S100 calcium binding protein A16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S100A16, S100 calcium binding protein A16
Synonyms

AAG13, DT1P1A7, S100F
Links

HGNC:20441

NCBI Gene ID: 140576

neXtProt AC: NX_Q96FQ6

UniProt: Q96FQ6
Chr Location

1q21.3; chr1:153606883-153613145 (-) GRCh38

MGI Vertebrate Homology

S100a16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: S100A16
Gene Tree

S100a16

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

1
Targeted

1
Transgenic

1
Genomic Mutations

2 involving S100a16
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a null allele exhibit protection from p;iver fibrosis induced by treatment with CCl4, bile duct ligation, or a methionine and choline deficient diet.

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All GO Annotations

19
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

26
cDNA Data

114
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

73
RefSeq

20
UniProt

2
CCDS

CCDS17536.1

Ensembl

ENSMUSG00000074457 (Evidence)
NCBI Gene

67860

			Length	Strain/Species	Flank
genomic	67860	NCBI Gene Model \| MGI Sequence Detail	5898	C57BL/6J	± kb
transcript	NM_001356607	RefSeq \| MGI Sequence Detail	1321	C57BL/6
polypeptide	Q9D708	UniProt \| EBI \| MGI Sequence Detail	124	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014408 protein S100-A16

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

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All nucleic 114

cDNA 114

Microarray probesets 3

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MGI:2139676, MGI:2139785

Summaries

All 47

Developmental Gene Expression 4

Diseases 1

Gene Ontology 4

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:342386 Wang D, et al., S100a16 Deficiency Prevents Alcohol-induced Fatty Liver Injury via Inducing MANF Expression in Mice. Int J Biol Sci. 2023;19(16):5074-5088

TSS for S100a16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30217	Chr3:90444537-90444548 (+)	-18 bp
Tssr30218	Chr3:90444549-90444577 (+)	2 bp
Tssr30219	Chr3:90444598-90444611 (+)	44 bp
Tssr30220	Chr3:90444613-90444633 (+)	62 bp
Tssr30221	Chr3:90444640-90444693 (+)	106 bp
Tssr30222	Chr3:90446952-90446967 (+)	2,399 bp
Tssr30223	Chr3:90446982-90446998 (+)	2,429 bp
Tssr30224	Chr3:90448462-90448480 (+)	3,910 bp
Tssr30225	Chr3:90448484-90448493 (+)	3,928 bp
Tssr30226	Chr3:90448496-90448520 (+)	3,947 bp
Tssr30227	Chr3:90448524-90448548 (+)	3,975 bp
Tssr30228	Chr3:90448565-90448583 (+)	4,013 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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