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Atg3 Gene Detail
Summary
  • Symbol
    Atg3
  • Name
    autophagy related 3
  • Synonyms
    2610016C12Rik, APG3, Apg3l, PC3-96
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915091
    NCBI Gene: 67841
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:45158785-45188538 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.45 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915091
protein coding gene Chr16:45158784-45188538 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022849
protein coding gene Chr16:43935079-43966212 (+)
A/J MGP_AJ_G0022814
protein coding gene Chr16:41956472-41989494 (+)
AKR/J MGP_AKRJ_G0022786
protein coding gene Chr16:43337161-43368675 (+)
BALB/cJ MGP_BALBcJ_G0022815
protein coding gene Chr16:41960319-41990023 (+)
C3H/HeJ MGP_C3HHeJ_G0022579
protein coding gene Chr16:43493364-43523084 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023262
protein coding gene Chr16:44923774-44958102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020776
protein coding gene Chr16:42358378-42388144 (+)
CAST/EiJ MGP_CASTEiJ_G0022104
protein coding gene Chr16:43681312-43711923 (+)
CBA/J MGP_CBAJ_G0022550
protein coding gene Chr16:46831314-46861015 (+)
DBA/2J MGP_DBA2J_G0022682
protein coding gene Chr16:41703116-41733700 (+)
FVB/NJ MGP_FVBNJ_G0022657
protein coding gene Chr16:41622885-41652486 (+)
LP/J MGP_LPJ_G0022750
protein coding gene Chr16:43672426-43702149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022676
protein coding gene Chr16:46240750-46272430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023277
protein coding gene Chr16:43361916-43391621 (+)
PWK/PhJ MGP_PWKPhJ_G0021844
protein coding gene Chr16:42068080-42098194 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021675
protein coding gene Chr16:43275638-43307327 (+)
WSB/EiJ MGP_WSBEiJ_G0022149
protein coding gene Chr16:43450307-43480816 (+)



Homology
more
  • Human Ortholog
    ATG3, autophagy related 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATG3, autophagy related 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APG3, APG3L, APG3-LIKE, PC3-96
  • Links
    NCBI Gene ID: 64422
    neXtProt AC: NX_Q9NT62
    UniProt: Q9NT62

  • Chr Location
    3q13.2; chr3:112532507-112561963 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in T cells exhibit decreased autophagy, decreased T cell proliferation, and increased T cell apoptosis. Mice homozygous for a knock-out allele exhibit decreased birth weight, neonatal lethality and abnormal autophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022663 Ensembl Gene Model | MGI Sequence Detail 29754 C57BL/6J ±  kb
    transcript ENSMUST00000023343 Ensembl | MGI Sequence Detail 2057 Not Applicable  
    polypeptide ENSMUSP00000023343 Ensembl | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 4
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:257717 Frudd K, et al., Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. Nat Commun. 2018 Jan 8;9(1):95

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory