Atg3
Gene Detail

Symbol Name ID

Atg3 autophagy related 3 MGI:1915091

Synonyms

2610016C12Rik, APG3, Apg3l, PC3-96

Feature Type

protein coding gene

Genetic Map

Chromosome 16

29.45 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:45158785-45188538 bp, + strand From VEGA annotation of GRCm38   29754 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: autophagy-related protein 3
Gene Tree: Atg3

Human homologs

Human Homolog		ATG3, autophagy related 3
NCBI Gene ID		64422
neXtProt AC		NX_Q9NT62
Human Synonyms		APG3, APG3L, APG3-LIKE, PC3-96
Human Chr (Location)		3q13.2; chr3:112251359-112280485 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a conditional allele activated in T cells exhibit decreased autophagy, increased mitochondria and endoplasmic reticulum content, decreased T cell proliferation, and increased T cell apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	autophagic vacuole assembly, autophagy, ...
Component	cytoplasm, cytoplasmic ubiquitin ligase complex, ...
Function	Atg12 ligase activity, Atg8 ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (28)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41

cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) cDNA(61)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000025355 (Evidence)
Ensembl Gene Model	ENSMUSG00000022663 (Evidence)
Entrez Gene	67841 (Evidence)
UniGene	41775
DFCI	TC1577632, TC1643369, TC1643644
DoTS	DT.101706474, DT.40136788, DT.491835
EC	6.3.2.-
Consensus CDS Project	CCDS28194.1
International Mouse Knockout Project Status	Atg3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025355	VEGA Gene Model | MGI Sequence Detail	29754	C57BL/6J
transcript	OTTMUST00000062424	VEGA | MGI Sequence Detail	2057	Not Applicable
polypeptide	OTTMUSP00000030762	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(32) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(172 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007135	Autophagy-related protein 3
InterPro	IPR019461	Autophagy-related protein 3, C-terminal
InterPro	IPR007134	Autophagy-related protein 3, N-terminal
Protein Ontology	PR:000004413	ubiquitin-like-conjugating enzyme ATG3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193133 Crawford SE, et al., Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-beta signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3405-13
All references(37)