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Gpsm1
Gene Detail
 Symbol
Name
ID
Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
MGI:1915089
Synonyms 1810037C22Rik, Ags3
Feature Type protein coding gene
Genetic Map
Chromosome 2
18.73 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:26315515-26348237 bp, + strand
From VEGA annotation of GRCm38

  32723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gpsm1

Human
homologs
Human Homolog GPSM1, G-protein signaling modulator 1
NCBI Gene ID 26086
neXtProt AC  NX_Q86YR5
Human Synonyms  AGS3
Human Chr (Location)  9q34.3; chr9:136327476-136359605 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit a lean phenotype, reduced fat mass, increased food consumption, increased nocturnal energy expenditure and altered blood pressure control mechanisms; surprisingly, their basal behavior and gross brain morphology remain normal.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Gpsm1 interacts with 139 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, endoplasmic reticulum, ...
Function GDP-dissociation inhibitor activity, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (45)    Tissues (8)    Images (24)
Theiler Stages: 11, 13, 23
Assay TypeResults
RNA in situ 45
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000012734 (Evidence)
Ensembl Gene ModelENSMUSG00000026930 (Evidence)
Entrez Gene67839 (Evidence)
NIA Mouse Gene IndexU001513
Consensus CDS ProjectCCDS15800.1, CCDS57158.1, CCDS57159.1
International Mouse Knockout Project StatusGpsm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012734 VEGA Gene Model | MGI Sequence Detail 32723 C57BL/6J ±  kb
transcript OTTMUST00000030402 VEGA | MGI Sequence Detail 3432 Not Applicable 
polypeptide OTTMUSP00000013669 VEGA | MGI Sequence Detail 705 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(175 from dbSNP Build 137)    SNPs within 2kb including multiple locations(181)
Protein-related
information
ResourceIDDescription
InterPro IPR003109 GoLoco motif
InterPro IPR024804 G-protein-signaling modulator 1
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000008204 G-protein-signaling modulator 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209753 Vural A, et al., Normal autophagic activity in macrophages from mice lacking Galphai3, AGS3, or RGS19. PLoS One. 2013;8(11):e81886
All references(38)
Other
accession IDs
MGI:2139300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory