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Gpsm1 Gene Detail
Summary
  • Symbol
    Gpsm1
  • Name
    G-protein signalling modulator 1 (AGS3-like, C. elegans)
  • Synonyms
    1810037C22Rik, Ags3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915089
    NCBI Gene: 67839
  • Gene Overview
    MyGene.info: GPSM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:26315515-26348237 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32723 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 18.73 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GPSM1, G protein signaling modulator 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GPSM1, G protein signaling modulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGS3
  • Links
    NCBI Gene ID: 26086
    neXtProt AC: NX_Q86YR5
    UniProt: Q86YR5

  • Chr Location
    9q34.3; chr9:136327476-136359605 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a lean phenotype, reduced fat mass, increased food consumption, increased nocturnal energy expenditure and altered blood pressure control mechanisms; surprisingly, their basal behavior and gross brain morphology remain normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012734 VEGA Gene Model | MGI Sequence Detail 32723 C57BL/6J ±  kb
    transcript OTTMUST00000030402 VEGA | MGI Sequence Detail 3432 Not Applicable  
    polypeptide OTTMUSP00000013669 VEGA | MGI Sequence Detail 705 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      167 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR003109 GoLoco motif
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139300
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:252171 Saadaoui M, et al., Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3. EMBO Rep. 2017 Sep;18(9):1509-1520

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory