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Idh3a Gene Detail
Summary
  • Symbol
    Idh3a
  • Name
    isocitrate dehydrogenase 3 (NAD+) alpha
  • Synonyms
    1500012E04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915084
    NCBI Gene: 67834
  • Gene Overview
    MyGene.info: IDH3A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:54586511-54604662 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18152 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IDH3A, isocitrate dehydrogenase 3 (NAD(+)) alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IDH3A, isocitrate dehydrogenase 3 (NAD(+)) alpha
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3419
    neXtProt AC: NX_P50213
    UniProt: P50213

  • Chr Location
    15q25.1; chr15:78149326-78170542 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit progressive retinal degeneration and decreased visual acuity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67834 NCBI Gene Model | MGI Sequence Detail 18152 C57BL/6J ±  kb
    transcript NM_029573 RefSeq | MGI Sequence Detail 2418 FVB/N  
    polypeptide Q9D6R2 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      125 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008889 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    • EC
    • InterPro Domains
      IPR004434 Isocitrate dehydrogenase NAD-dependent
      IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
      IPR024084 Isopropylmalate dehydrogenase-like domain
    Molecular
    Reagents
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    • All nucleic 224
      cDNA 224

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1923550, MGI:2142905, MGI:2143014
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory