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Idh3a Gene Detail
Summary
  • Symbol
    Idh3a
  • Name
    isocitrate dehydrogenase 3 (NAD+) alpha
  • Synonyms
    1500012E04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915084
    NCBI Gene: 67834
  • Gene Overview
    MyGene.info: IDH3A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54586511-54604662 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915084
protein coding gene Chr9:54586334-54604662 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034826
protein coding gene Chr9:53638241-53656385 (+)
A/J MGP_AJ_G0034807
protein coding gene Chr9:51924038-51942182 (+)
AKR/J MGP_AKRJ_G0034735
protein coding gene Chr9:53101132-53119282 (+)
BALB/cJ MGP_BALBcJ_G0034799
protein coding gene Chr9:51698692-51717092 (+)
C3H/HeJ MGP_C3HHeJ_G0034509
protein coding gene Chr9:53567636-53587836 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035318
protein coding gene Chr9:55144127-55162131 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032230
protein coding gene Chr9:51338463-51356301 (+)
CAST/EiJ MGP_CASTEiJ_G0033831
protein coding gene Chr9:53575762-53597265 (+)
CBA/J MGP_CBAJ_G0034480
protein coding gene Chr9:57031992-57054402 (+)
DBA/2J MGP_DBA2J_G0034639
protein coding gene Chr9:51814646-51832748 (+)
FVB/NJ MGP_FVBNJ_G0034581
protein coding gene Chr9:51016655-51034789 (+)
LP/J MGP_LPJ_G0034721
protein coding gene Chr9:53947714-53965858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034624
protein coding gene Chr9:58599684-58617756 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035340
protein coding gene Chr9:53104978-53122925 (+)
PWK/PhJ MGP_PWKPhJ_G0033535
protein coding gene Chr9:51790705-51809195 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033370
protein coding gene Chr9:53375033-53393038 (+)
WSB/EiJ MGP_WSBEiJ_G0033943
protein coding gene Chr9:53082136-53100215 (+)



Homology
more
  • Human Ortholog
    IDH3A, isocitrate dehydrogenase 3 (NAD(+)) alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IDH3A, isocitrate dehydrogenase 3 (NAD(+)) alpha
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3419
    neXtProt AC: NX_P50213
    UniProt: P50213

  • Chr Location
    15q25.1; chr15:78149326-78170542 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit progressive retinal degeneration and decreased visual acuity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67834 NCBI Gene Model | MGI Sequence Detail 18152 C57BL/6J ±  kb
    transcript NM_029573 RefSeq | MGI Sequence Detail 2418 FVB/N  
    polypeptide Q9D6R2 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008889 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    • EC
    • InterPro Domains
      IPR004434 Isocitrate dehydrogenase NAD-dependent
      IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
      IPR024084 Isopropylmalate dehydrogenase-like domain
    Molecular
    Reagents
    less
    • All nucleic 225
      cDNA 225

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1923550, MGI:2142905, MGI:2143014
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory