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Aldh6a1 Gene Detail
Summary
  • Symbol
    Aldh6a1
  • Name
    aldehyde dehydrogenase family 6, subfamily A1
  • Synonyms
    1110038I05Rik, MGC:37325, Mmsdh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915077
    NCBI Gene: 104776
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84477491-84497778 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915077
protein coding gene Chr12:84477491-84497798 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019938
protein coding gene Chr12:85139992-85160834 (-)
A/J MGP_AJ_G0019895
protein coding gene Chr12:81914917-81935142 (-)
AKR/J MGP_AKRJ_G0019871
protein coding gene Chr12:84131905-84152132 (-)
BALB/cJ MGP_BALBcJ_G0019875
protein coding gene Chr12:82247750-82267965 (-)
C3H/HeJ MGP_C3HHeJ_G0019681
protein coding gene Chr12:84598047-84618274 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020326
protein coding gene Chr12:87592186-87612411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017944
protein coding gene Chr12:78815852-78835619 (-)
CAST/EiJ MGP_CASTEiJ_G0019230
protein coding gene Chr12:79552195-79576342 (-)
CBA/J MGP_CBAJ_G0019652
protein coding gene Chr12:90973775-90995533 (-)
DBA/2J MGP_DBA2J_G0019767
protein coding gene Chr12:81443526-81464346 (-)
FVB/NJ MGP_FVBNJ_G0019753
protein coding gene Chr12:80400243-80420472 (-)
LP/J MGP_LPJ_G0019839
protein coding gene Chr12:85019899-85041296 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019792
protein coding gene Chr12:93882084-93903413 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020360
protein coding gene Chr12:83725519-83745771 (-)
PWK/PhJ MGP_PWKPhJ_G0018994
protein coding gene Chr12:75933426-75954905 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018789
protein coding gene Chr12:78221329-78241933 (-)
WSB/EiJ MGP_WSBEiJ_G0019282
protein coding gene Chr12:84443824-84464482 (-)



Homology
more
  • Human Ortholog
    ALDH6A1, aldehyde dehydrogenase 6 family member A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDH6A1, aldehyde dehydrogenase 6 family member A1
  • Synonyms
    MMSADHA, MMSDH
  • Links
    NCBI Gene ID: 4329
    neXtProt AC: NX_Q02252
    UniProt: Q02252

  • Chr Location
    14q24.3; chr14:74056847-74084492 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021238 Ensembl Gene Model | MGI Sequence Detail 20288 C57BL/6J ±  kb
transcript ENSMUST00000085192 Ensembl | MGI Sequence Detail 3399 Not Applicable  
polypeptide ENSMUSP00000082288 Ensembl | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003930 methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
  • EC
  • InterPro Domains
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR016162 Aldehyde dehydrogenase, N-terminal
    IPR016161 Aldehyde/histidinol dehydrogenase
    IPR010061 Methylmalonate-semialdehyde dehydrogenase
Molecular
Reagents
less
  • All nucleic 143
    cDNA 142
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1888689, MGI:2144782
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory