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Aldh6a1
Gene Detail
 Symbol
Name
ID
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
MGI:1915077
Synonyms 1110038I05Rik, MGC:37325, Mmsdh
Feature Type protein coding gene
Genetic Map
Chromosome 12
39.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:84430723-84450950 bp, - strand
From Ensembl annotation of GRCm38

  20228 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh6a1

Human
homologs
Human Homolog ALDH6A1, aldehyde dehydrogenase 6 family, member A1
NCBI Gene ID 4329
neXtProt AC  NX_Q02252
Human Synonyms  MMSADHA, MMSDH
Human Chr (Location)  14q24.3; chr14:74057662-74084493 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALDH6A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Aldh6a1 interacts with 264 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process beta-alanine catabolic process, brown fat cell differentiation, ...
Component extracellular vesicular exosome, mitochondrion, ...
Function malonate-semialdehyde dehydrogenase (acetylating) activity, methylmalonate-semialdehyde dehydrogenase (acylating) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (249)    Tissues (136)    Images (38)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 249
cDNA source data(141)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(142) cDNA(141) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000021238 (Evidence)
Entrez Gene104776 (Evidence)
UniGene247510
DFCITC1573320
DoTSDT.101344408, DT.101376370, DT.110919524, DT.480734, DT.87028754, DT.99863935
NIA Mouse Gene IndexU034171
EC1.2.1.18, 1.2.1.27
Consensus CDS ProjectCCDS26046.1
International Mouse Knockout Project StatusAldh6a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021238 Ensembl Gene Model | MGI Sequence Detail 20228 C57BL/6J ±  kb
transcript ENSMUST00000085192 Ensembl | MGI Sequence Detail 3340 Not Applicable 
polypeptide ENSMUSP00000082288 Ensembl | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(165 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
InterPro IPR010061 Methylmalonate-semialdehyde dehydrogenase
Protein Ontology PR:000003930 methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:1888689, MGI:2144782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory